|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0009079,
umls-concept:C0017890,
umls-concept:C0025914,
umls-concept:C0026336,
umls-concept:C0026339,
umls-concept:C0026809,
umls-concept:C0036341,
umls-concept:C0080093,
umls-concept:C0205145,
umls-concept:C0870432,
umls-concept:C1280500,
umls-concept:C1555465,
umls-concept:C1705417,
umls-concept:C1709060,
umls-concept:C1721807,
umls-concept:C2348205
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pubmed:issue |
1
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|
pubmed:dateCreated |
2005-4-11
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|
pubmed:abstractText |
Schizophrenia is characterized by disturbances in sensorimotor gating and attentional processes, which can be measured by prepulse inhibition (PPI) and latent inhibition (LI), respectively. Research has implicated dysfunction of neurotransmission at the NMDA-type glutamate receptor in this disorder.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0033-3158
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
179
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
54-67
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15759151-Amino Acid Transport Systems, Neutral,
pubmed-meshheading:15759151-Animals,
pubmed-meshheading:15759151-Attention,
pubmed-meshheading:15759151-Clozapine,
pubmed-meshheading:15759151-Conditioning (Psychology),
pubmed-meshheading:15759151-Disease Models, Animal,
pubmed-meshheading:15759151-Dizocilpine Maleate,
pubmed-meshheading:15759151-Glycine Plasma Membrane Transport Proteins,
pubmed-meshheading:15759151-Male,
pubmed-meshheading:15759151-Mice,
pubmed-meshheading:15759151-Mice, Inbred C57BL,
pubmed-meshheading:15759151-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:15759151-Schizophrenia,
pubmed-meshheading:15759151-Serine
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|
pubmed:year |
2005
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pubmed:articleTitle |
Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia.
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pubmed:affiliation |
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. lipina@mshri.on.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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