| pubmed-article:15741797 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15741797 | lifeskim:mentions | umls-concept:C1565860 | lld:lifeskim |
| pubmed-article:15741797 | lifeskim:mentions | umls-concept:C1705323 | lld:lifeskim |
| pubmed-article:15741797 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:15741797 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:15741797 | lifeskim:mentions | umls-concept:C0286651 | lld:lifeskim |
| pubmed-article:15741797 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15741797 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15741797 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15741797 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15741797 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15741797 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15741797 | pubmed:dateCreated | 2005-3-2 | lld:pubmed |
| pubmed-article:15741797 | pubmed:abstractText | Increasing evidence shows the importance of platelet-endothelial cell interactions in the progression of atherosclerosis. Platelets contribute to coronary events both as major components of thrombi and as a triggering factor in inflammation that leads to plaque vulnerability. Recent data suggest that statins, besides their lipid-lowering properties, exert pleiotropic effects that may be beneficial in atherosclerosis. Whether activated platelets influence cyclooxygenase-2 (COX-2) expression in human umbilical vein endothelial cells (HUVEC), the effect of atorvastatin, and possible mechanisms were investigated. COX-2 gene expression in HUVEC was studied using real-time polymerase chain reaction. CD40 ligand surface expression of platelets was tested by fluorescence-activated cell sorting analyses. Activated platelets significantly up-regulated COX-2 gene expression in HUVEC. Co-incubation of platelets with atorvastatin was shown to reverse this up-regulation via reduction of CD40 ligand surface expression on platelets. Data suggest that atorvastatin influences CD40-CD40-ligand-dependent platelet-endothelial interaction and that this influence affects platelet-induced COX-2 expression in HUVEC. | lld:pubmed |
| pubmed-article:15741797 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15741797 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15741797 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15741797 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15741797 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15741797 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15741797 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15741797 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15741797 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15741797 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15741797 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:15741797 | pubmed:issn | 0957-5235 | lld:pubmed |
| pubmed-article:15741797 | pubmed:author | pubmed-author:KaneiderNicol... | lld:pubmed |
| pubmed-article:15741797 | pubmed:author | pubmed-author:WiedermannChr... | lld:pubmed |
| pubmed-article:15741797 | pubmed:author | pubmed-author:PatschJosef... | lld:pubmed |
| pubmed-article:15741797 | pubmed:author | pubmed-author:DjananiAngela... | lld:pubmed |
| pubmed-article:15741797 | pubmed:author | pubmed-author:FeistritzerCl... | lld:pubmed |
| pubmed-article:15741797 | pubmed:author | pubmed-author:SturnDaniel... | lld:pubmed |
| pubmed-article:15741797 | pubmed:author | pubmed-author:MosheimerBirg... | lld:pubmed |
| pubmed-article:15741797 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15741797 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:15741797 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15741797 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15741797 | pubmed:pagination | 105-10 | lld:pubmed |
| pubmed-article:15741797 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15741797 | pubmed:meshHeading | pubmed-meshheading:15741797... | lld:pubmed |
| pubmed-article:15741797 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15741797 | pubmed:articleTitle | CD40-ligand-dependent induction of COX-2 gene expression in endothelial cells by activated platelets: inhibitory effects of atorvastatin. | lld:pubmed |
| pubmed-article:15741797 | pubmed:affiliation | Division of General Internal Medicine, Department of Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria. | lld:pubmed |
| pubmed-article:15741797 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15741797 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15741797 | lld:pubmed |
