|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2005-1-24
|
|
pubmed:abstractText |
Electropharmacological effect of the antipsychotic and antiemetic drug prochlorperazine was assessed using the halothane-anesthetized in vivo canine model (n = 5). Up to 10 times higher than the clinically relevant doses of prochlorperazine (< or = 3 mg/kg, i.v.) did not induce cardiohemodynamic collapse in the model. Meanwhile, clinically relevant to supratherapeutic doses (0.3 - 3 mg/kg, i.v.) prolonged the ventricular repolarization period in a dose-related and reverse-use dependent manner that could become proarrhythmic substrates. Thus, caution has to be paid on the use of prochlorperazine particularly for patients with risks of the elevated plasma drug concentration, compromised cardiac repolarization, and/or frequent ventricular premature beats.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1347-8613
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
97
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
101-6
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:15655290-Action Potentials,
pubmed-meshheading:15655290-Animals,
pubmed-meshheading:15655290-Antiemetics,
pubmed-meshheading:15655290-Antipsychotic Agents,
pubmed-meshheading:15655290-Blood Pressure,
pubmed-meshheading:15655290-Bundle of His,
pubmed-meshheading:15655290-Cardiac Output,
pubmed-meshheading:15655290-Cardiac Pacing, Artificial,
pubmed-meshheading:15655290-Disease Models, Animal,
pubmed-meshheading:15655290-Dogs,
pubmed-meshheading:15655290-Dose-Response Relationship, Drug,
pubmed-meshheading:15655290-Drug Evaluation, Preclinical,
pubmed-meshheading:15655290-Electrocardiography,
pubmed-meshheading:15655290-Female,
pubmed-meshheading:15655290-Heart Rate,
pubmed-meshheading:15655290-Heart Ventricles,
pubmed-meshheading:15655290-Infusions, Intravenous,
pubmed-meshheading:15655290-Male,
pubmed-meshheading:15655290-Prochlorperazine,
pubmed-meshheading:15655290-Refractory Period, Electrophysiological,
pubmed-meshheading:15655290-Vascular Resistance,
pubmed-meshheading:15655290-Ventricular Function,
pubmed-meshheading:15655290-Ventricular Function, Left,
pubmed-meshheading:15655290-Ventricular Pressure
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
The antipsychotic and antiemetic drug prochlorperazine delays the ventricular repolarization of the in situ canine heart.
|
|
pubmed:affiliation |
Department of Medicine, Koshu Rehabilitation Hospital, Faefuki-city, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
