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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-1-13
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pubmed:abstractText |
The proinflammatory chemokine interleukin-8 (IL-8) induces chondrocyte hypertrophy. Moreover, chondrocyte hypertrophy develops in situ in osteoarthritic (OA) articular cartilage and promotes dysregulated matrix repair and calcification. Growth plate chondrocyte hypertrophy is associated with expression of the type III sodium-dependent inorganic phosphate (Pi) cotransporter phosphate transporter/retrovirus receptor 1 (PiT-1). This study was undertaken to test the hypothesis that IL-8 promotes chondrocyte hypertrophy by modulating chondrocyte PiT-1 expression and sodium-dependent Pi uptake, and to assess differential roles in this activity.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
144-54
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15641067-Cartilage, Articular,
pubmed-meshheading:15641067-Cell Differentiation,
pubmed-meshheading:15641067-Cells, Cultured,
pubmed-meshheading:15641067-Chondrocytes,
pubmed-meshheading:15641067-Focal Adhesion Kinase 2,
pubmed-meshheading:15641067-Humans,
pubmed-meshheading:15641067-Hypertrophy,
pubmed-meshheading:15641067-Interleukin-8,
pubmed-meshheading:15641067-Osteoarthritis,
pubmed-meshheading:15641067-Phosphate Transport Proteins,
pubmed-meshheading:15641067-Phosphates,
pubmed-meshheading:15641067-Protein-Tyrosine Kinases,
pubmed-meshheading:15641067-Receptors, Interleukin-8A,
pubmed-meshheading:15641067-Recombinant Proteins,
pubmed-meshheading:15641067-Sodium,
pubmed-meshheading:15641067-Up-Regulation
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pubmed:year |
2005
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pubmed:articleTitle |
Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes.
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pubmed:affiliation |
Veterans Affairs Medical Center, University of California-San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, USA. rterkeltaub@ucsd.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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