| pubmed-article:15583831 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15583831 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15583831 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:15583831 | lifeskim:mentions | umls-concept:C0225360 | lld:lifeskim |
| pubmed-article:15583831 | lifeskim:mentions | umls-concept:C0009368 | lld:lifeskim |
| pubmed-article:15583831 | lifeskim:mentions | umls-concept:C1311140 | lld:lifeskim |
| pubmed-article:15583831 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:15583831 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15583831 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15583831 | pubmed:dateCreated | 2004-12-7 | lld:pubmed |
| pubmed-article:15583831 | pubmed:abstractText | The recently identified cytokine interleukin-23 (IL-23) consists of p19 and p40 subunits. The major cellular source of IL-23 is dendritic cells and/or macrophages. We investigated the expression of IL-23 p19 mRNA in human colonic subepithelial myofibroblasts (SEMFs). p19 mRNA was not expressed in unstimulated SEMFs, but IL-1beta and TNF-alpha strongly induced p19 mRNA expression in these cells. The effects of IL-1beta were much stronger than those of TNF-alpha. These responses were observed in both a dose- and time-dependent manner. Furthermore, these cytokines acted synergistically when used in combination. A blockade of NF-kappaB activation by the overexpression of a stable form of IkappaBalpha completely blocked these responses, indicating that the induction of p19 mRNA expression by IL-1beta and TNF-alpha was mediated by the NF-kappaB activation pathway. In conclusion, this is the first report demonstrating that IL-23 p19 mRNA is inducible in colonic myofibroblasts by IL-1beta and TNF-alpha. The p19 expression in these cells might play a role in mucosal immune responses. | lld:pubmed |
| pubmed-article:15583831 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15583831 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15583831 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15583831 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15583831 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15583831 | pubmed:issn | 1107-3756 | lld:pubmed |
| pubmed-article:15583831 | pubmed:author | pubmed-author:UzuNN | lld:pubmed |
| pubmed-article:15583831 | pubmed:author | pubmed-author:FujiyamaYoshi... | lld:pubmed |
| pubmed-article:15583831 | pubmed:author | pubmed-author:HataKazunoriK | lld:pubmed |
| pubmed-article:15583831 | pubmed:author | pubmed-author:ShimizuNobuyo... | lld:pubmed |
| pubmed-article:15583831 | pubmed:author | pubmed-author:TsujikawaTomo... | lld:pubmed |
| pubmed-article:15583831 | pubmed:author | pubmed-author:TakayanagiAts... | lld:pubmed |
| pubmed-article:15583831 | pubmed:author | pubmed-author:YasuiHirofumi... | lld:pubmed |
| pubmed-article:15583831 | pubmed:author | pubmed-author:InatomiOsamuO | lld:pubmed |
| pubmed-article:15583831 | pubmed:author | pubmed-author:ZhangZhuobinZ | lld:pubmed |
| pubmed-article:15583831 | pubmed:author | pubmed-author:KitohKatsuyuk... | lld:pubmed |
| pubmed-article:15583831 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15583831 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:15583831 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15583831 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15583831 | pubmed:pagination | 79-83 | lld:pubmed |
| pubmed-article:15583831 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15583831 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15583831 | pubmed:articleTitle | Interleukin-1beta and tumor necrosis factor-alpha upregulate interleukin-23 subunit p19 gene expression in human colonic subepithelial myofibroblasts. | lld:pubmed |
| pubmed-article:15583831 | pubmed:affiliation | Department of Internal Medicine, Shiga University of Medical Science, Seta-Tukinowa, Otsu 520-2192, Japan. | lld:pubmed |
| pubmed-article:15583831 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15583831 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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