Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2004-12-6
pubmed:abstractText
Tumor necrosis factor (TNF) is critical for the control of visceral leishmaniasis caused by Leishmania donovani. However, the role of the related cytokine lymphotoxin (LT) alpha in this infection is unknown. Here we report that C57BL/6 mice deficient in TNF (B6.TNF(-/-)) or LT alpha (B6.LT alpha(-/-)) have increased susceptibility to hepatic L. donovani infection. Furthermore, the outcome of infection in bone marrow chimeric mice is dependent on donor hematopoietic cells, indicating that developmental defects in lymphoid organs were not responsible for increased susceptibility to L. donovani. Although both LT alpha and TNF regulated the migration of leukocytes into the sinusoidal area of the infected liver, their roles were distinct. LT alpha was essential for migration of leukocytes from periportal areas, an event consistent with LT alpha-dependent up-regulation of VCAM-1 on liver sinusoid lining cells, whereas TNF was essential for leukocyte recruitment to the liver. During visceral leishmaniasis, both cytokines were produced by radio-resistant cells and by CD4(+) T cells. LT alpha and TNF production by the former was required for granuloma assembly, while production of these cytokines by CD4(+) T cells was necessary to control parasite growth. The production of inducible nitric oxide synthase was also found to be deficient in TNF- and LT alpha-deficient infected mice. These results demonstrate that both LT alpha and TNF are required for control of L. donovani infection in noncompensatory ways.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-10229834, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-10689296, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-11035737, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-11208864, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-11238648, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-11239407, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-11298345, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-11672536, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-11854219, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-12021316, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-12163368, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-12426569, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-12436111, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-12439617, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-12446781, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-12528108, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-12568117, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-12622777, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-12627232, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-12648734, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-12794148, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-1281193, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-14517552, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-14593215, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-14635012, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-14987295, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-1541824, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-1590993, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-3027565, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-3139757, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-3290381, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-7507411, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-7636227, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-7846035, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-7916655, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-7990930, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-7995944, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-8021511, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-8171316, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-8171322, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-8171323, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-8381516, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-8387893, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-8648116, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-8690913, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-8878796, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-8879212, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-9103448, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-9133428, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-9223320, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-9256477, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-9368616, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-9462508, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-9521077, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-9552007, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-9565643, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-9697836, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-9780188, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-9834083, http://linkedlifedata.com/resource/pubmed/commentcorrection/15579454-9989990
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
165
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2123-33
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...