Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-1-25
pubmed:abstractText
BimC kinesins are required for mitotic spindle assembly in a variety of organisms. These proteins are localized to centrosomes, spindle microtubules, and the spindle midzone. We have previously shown that the Caenorhabditis elegans Aurora B kinase AIR-2 is required for the localization of the ZEN-4 kinesin protein to midzone microtubules. To determine whether the association of BimC kinesins with spindle microtubules is also dependent on AIR-2, we examined the expression pattern of BMK-1, a C. elegans BimC kinesin, in wild-type and AIR-2-deficient embryos. BMK-1 is highly expressed in the hermaphrodite gonad and is localized to meiotic spindle microtubules in the newly fertilized embryo. In mitotic embryos, BMK-1 is associated with spindle microtubules from prophase through anaphase and is concentrated at the spindle midzone during anaphase and telophase. In the absence of AIR-2, BMK-1 localization to meiotic and mitotic spindles is greatly reduced. This is not a consequence of loss of ZEN-4 localization because BMK-1 is appropriately localized in ZEN-4-deficient embryos. Furthermore, AIR-2 and BMK-1 directly interact with one another and the C-terminal tail domain of BMK-1 is specifically phosphorylated by AIR-2 in vitro. Together with our previous data, these results suggest that at least one function of the Aurora B kinases is to recruit spindle-associated motor proteins to their sites of action.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-10329703, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-10385519, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-10511710, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-10580983, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-10912796, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-10983970, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-11050384, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-11050385, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-11166196, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-11171318, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-11266459, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-11748251, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-11792803, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-11872139, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-11940606, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-11942622, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-12048181, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-12408861, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-12707312, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-1406972, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-1406973, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-1538784, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-1618897, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-1710028, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-2138511, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-2145514, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-4366476, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-7753799, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-7940758, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-8026619, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-8227131, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-8548803, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-8674121, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-8978031, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-9187145, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-9201714, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-9585508, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-9693365, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-9701554, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-9778499, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-9778533, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-9804418, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-9852156, http://linkedlifedata.com/resource/pubmed/commentcorrection/15548597-9885249
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/AIR-2 protein, C elegans, http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase, http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Kinesin, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 7, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Threonine, http://linkedlifedata.com/resource/pubmed/chemical/ZEN-4 protein, C elegans, http://linkedlifedata.com/resource/pubmed/chemical/aurora kinase
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1059-1524
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
742-56
pubmed:dateRevised
2011-7-11
pubmed:meshHeading
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