Source:http://linkedlifedata.com/resource/pubmed/id/15502805
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2005-3-21
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| pubmed:abstractText |
Diagnostic use of antibodies against aquaporin water channel proteins and PAX-2, a nuclear transcription factor in renal development, was tested in 202 renal neoplasms, using tissue microarray technique. Immunohistochemistry for aquaporin-1, aquaporin-2, PAX-2, CD10, and cytokeratin 7 was performed on 102 clear cell renal cell carcinomas, 44 papillary renal cell carcinomas (among them 34 type 1 and 10 type 2), 24 chromophobe renal cell carcinomas, three collecting duct carcinomas (carcinomas of the collecting ducts of Bellini), and 29 oncocytomas. Aquaporin-1 expression was found in clear cell renal cell carcinomas and papillary renal cell carcinomas of both types (78 and 73%, respectively), but not in chromophobe renal cell carcinomas, collecting duct carcinomas, and oncocytomas. Aquaporin-2 expression was not seen in any of the tested tumors. PAX-2 and CD10 was found in the majority of clear cell renal cell carcinomas (88 and 85%, respectively) but only in few papillary renal cell carcinomas, chromophobe renal cell carcinomas and oncocytomas. Decrease or loss of aquaporin-1 and PAX-2 was shown in higher grades compared to lower grades of clear cell renal cell carcinomas (P<0.0001 and <0.0245, respectively). Cytokeratin 7 was rarely seen in clear cell renal cell carcinomas, type 2 papillary renal cell carcinomas, and oncocytomas, but was found in the majority of type 1 papillary renal cell carcinomas (97.1%) and chromophobe renal cell carcinomas (88%). Aquaporin-1 and PAX-2 expression was found to correlate with nuclear grading for clear cell renal cell carcinomas but not for papillary renal cell carcinomas. No correlation of tumor stage and aquaporin-1 and PAX-2 expression was seen. Aquaporin-1 and PAX-2 are reliable markers for clear cell renal cell carcinomas of lower grades but not for higher grades. CD10 expression remains stable, independent of nuclear grading.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AQP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/AQP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Aquaporin 1,
http://linkedlifedata.com/resource/pubmed/chemical/Aquaporin 2,
http://linkedlifedata.com/resource/pubmed/chemical/Aquaporins,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Group Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/KRT7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Keratin-7,
http://linkedlifedata.com/resource/pubmed/chemical/Keratins,
http://linkedlifedata.com/resource/pubmed/chemical/Neprilysin,
http://linkedlifedata.com/resource/pubmed/chemical/PAX2 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/PAX2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
0893-3952
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
18
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
535-40
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:15502805-Adenocarcinoma, Clear Cell,
pubmed-meshheading:15502805-Adenoma, Oxyphilic,
pubmed-meshheading:15502805-Aquaporin 1,
pubmed-meshheading:15502805-Aquaporin 2,
pubmed-meshheading:15502805-Aquaporins,
pubmed-meshheading:15502805-Blood Group Antigens,
pubmed-meshheading:15502805-Carcinoma, Papillary,
pubmed-meshheading:15502805-Carcinoma, Renal Cell,
pubmed-meshheading:15502805-DNA-Binding Proteins,
pubmed-meshheading:15502805-Humans,
pubmed-meshheading:15502805-Immunohistochemistry,
pubmed-meshheading:15502805-Keratin-7,
pubmed-meshheading:15502805-Keratins,
pubmed-meshheading:15502805-Kidney,
pubmed-meshheading:15502805-Kidney Neoplasms,
pubmed-meshheading:15502805-Neoplasm Staging,
pubmed-meshheading:15502805-Neprilysin,
pubmed-meshheading:15502805-PAX2 Transcription Factor,
pubmed-meshheading:15502805-Tissue Array Analysis,
pubmed-meshheading:15502805-Transcription Factors,
pubmed-meshheading:15502805-Tumor Markers, Biological
|
| pubmed:year |
2005
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| pubmed:articleTitle |
Expression of aquaporins and PAX-2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study.
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| pubmed:affiliation |
Department of Clinical Pathology, Medical University of Vienna, AKH Vienna, Vienna, Austria.
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| pubmed:publicationType |
Journal Article,
Comparative Study
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