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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2004-10-11
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pubmed:abstractText |
Mitogen-activated protein kinase (MAPK) plays a pivotal role in signal transduction. Activation of MAPK is regulated by upstream kinases including KRAS and BRAF, which are frequently mutated in low-grade ovarian serous carcinoma. This study evaluates the expression of active MAPK in ovarian serous carcinomas, with response to treatment and survival.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6432-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15475429-Adult,
pubmed-meshheading:15475429-Aged,
pubmed-meshheading:15475429-Aged, 80 and over,
pubmed-meshheading:15475429-Antineoplastic Agents,
pubmed-meshheading:15475429-Blotting, Western,
pubmed-meshheading:15475429-Carboplatin,
pubmed-meshheading:15475429-Cell Proliferation,
pubmed-meshheading:15475429-Cisplatin,
pubmed-meshheading:15475429-Cystadenocarcinoma, Serous,
pubmed-meshheading:15475429-DNA Mutational Analysis,
pubmed-meshheading:15475429-Drug Resistance, Neoplasm,
pubmed-meshheading:15475429-Female,
pubmed-meshheading:15475429-Follow-Up Studies,
pubmed-meshheading:15475429-Humans,
pubmed-meshheading:15475429-Immunohistochemistry,
pubmed-meshheading:15475429-Middle Aged,
pubmed-meshheading:15475429-Mitogen-Activated Protein Kinases,
pubmed-meshheading:15475429-Mutation,
pubmed-meshheading:15475429-Oncogene Protein p21(ras),
pubmed-meshheading:15475429-Ovarian Neoplasms,
pubmed-meshheading:15475429-Paclitaxel,
pubmed-meshheading:15475429-Proto-Oncogene Proteins B-raf,
pubmed-meshheading:15475429-Survival Analysis,
pubmed-meshheading:15475429-Tumor Cells, Cultured
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pubmed:year |
2004
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pubmed:articleTitle |
Characterization of active mitogen-activated protein kinase in ovarian serous carcinomas.
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pubmed:affiliation |
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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