Linked Life Data

1539650

Source:http://linkedlifedata.com/resource/pubmed/id/1539650

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 1
pubmed:dateCreated
1992-3-31
pubmed:abstractText
The requirement of parathyroid tissue for bone mineral loss during lactation was investigated. Lactating rats parathyroidectomized (PTX) at day 2 of lactation and consuming a 2% calcium diet are hypercalcemic and hypophosphatemic at day 13 of lactation. The high-calcium diet supports normal growth of pups nursing PTX mothers. PTX lactating rats mobilize bone mineral to the same extent as euparathyroid lactating rats consuming the same diet. Non-lactating PTX rats lose no bone mineral over a similar time period, indicating lactation-specific bone mineral mobilization in the absence of parathyroid tissue. PTX rats were verified to have physiologically insignificant amounts of parathyroid tissue, as evidenced by severe hypocalcemia and/or death in each rat after a shift from a 2% calcium to a 0.02% calcium diet. These results conclusively demonstrate that lactation-associated bone mineral mobilization does not require parathyroid hormone or parathyroid tissue.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
262
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
E230-3
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Bone mineral loss during lactation occurs in absence of parathyroid tissue.
pubmed:affiliation
Department of Biochemistry, University of Wisconsin-Madison, College of Agricultural and Life Sciences 53706.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't