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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2004-7-22
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pubmed:abstractText |
Phosphorylcholine (ChoP) is commonly expressed at the surface of pathogens of the respiratory tract, including Streptococcus pneumoniae and Neisseria meningitidis. We designed a synthetic hapten comprising ChoP and part of its native carrier structure in S. pneumoniae, i.e. N-acetyl-D-galactosamine (GalNAc). Protein conjugates of this hapten induced GalNAc-ChoP-specific antibodies which recognized ChoP on both S. pneumoniae and N. meningitidis. GalNAc-ChoP could therefore lead to the rational design of a novel multipurpose vaccine against respiratory infections.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3916-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15267227-Acetylgalactosamine,
pubmed-meshheading:15267227-Animals,
pubmed-meshheading:15267227-Antibody Formation,
pubmed-meshheading:15267227-Antigens, Bacterial,
pubmed-meshheading:15267227-Bacterial Vaccines,
pubmed-meshheading:15267227-Haptens,
pubmed-meshheading:15267227-Mice,
pubmed-meshheading:15267227-Neisseria meningitidis,
pubmed-meshheading:15267227-Phosphorylcholine,
pubmed-meshheading:15267227-Respiratory Tract Infections,
pubmed-meshheading:15267227-Serum Albumin,
pubmed-meshheading:15267227-Streptococcus pneumoniae,
pubmed-meshheading:15267227-Tetanus Toxin
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pubmed:year |
2004
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pubmed:articleTitle |
Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections.
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pubmed:affiliation |
Unité de Chimie Organique URA CNRS 2128, Institut Pasteur, Paris, France. sbay@pasteur.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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