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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2004-7-16
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pubmed:abstractText |
Previous studies by our laboratory have demonstrated that parathyroid hormone-related protein (PTHrP) and its receptor (PTH/PTHrP receptor) are commonly expressed in pancreatic cancer and suggest their participation in the progression of this devastating disease. It has also been demonstrated that one of the major hallmarks of pancreatic adenocarcinoma is an increased production of the extracellular matrix (ECM), a critical regulator of diverse cellular processes such as differentiation, proliferation, and angiogenesis. The present study focused on the relationship between the PTHrP and ECM axes in the pathobiology of pancreatic cancer.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fibronectins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Laminin,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone-Related Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Parathyroid Hormone...,
http://linkedlifedata.com/resource/pubmed/chemical/Tenascin,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Vitronectin
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1536-4828
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
85-92
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15257098-Adenocarcinoma,
pubmed-meshheading:15257098-Animals,
pubmed-meshheading:15257098-Cattle,
pubmed-meshheading:15257098-Cell Division,
pubmed-meshheading:15257098-Cell Line, Tumor,
pubmed-meshheading:15257098-Collagen,
pubmed-meshheading:15257098-Extracellular Matrix,
pubmed-meshheading:15257098-Extracellular Matrix Proteins,
pubmed-meshheading:15257098-Fibronectins,
pubmed-meshheading:15257098-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:15257098-Humans,
pubmed-meshheading:15257098-Intercellular Adhesion Molecule-1,
pubmed-meshheading:15257098-Laminin,
pubmed-meshheading:15257098-Mice,
pubmed-meshheading:15257098-Neoplasm Proteins,
pubmed-meshheading:15257098-Pancreatic Neoplasms,
pubmed-meshheading:15257098-Parathyroid Hormone-Related Protein,
pubmed-meshheading:15257098-Protein Isoforms,
pubmed-meshheading:15257098-Receptor, Parathyroid Hormone, Type 1,
pubmed-meshheading:15257098-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15257098-Tenascin,
pubmed-meshheading:15257098-Vascular Cell Adhesion Molecule-1,
pubmed-meshheading:15257098-Vitronectin
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pubmed:year |
2004
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pubmed:articleTitle |
The extracellular matrix differentially regulates the expression of PTHrP and the PTH/PTHrP receptor in FG pancreatic cancer cells.
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pubmed:affiliation |
Department of Surgery, University of California, San Diego and San Diego Veterans Affairs Medical Center, San Diego, California 92161, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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