Source:http://linkedlifedata.com/resource/pubmed/id/15240622
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2004-7-8
|
| pubmed:abstractText |
Persistent or recurrent disease is rare in low risk patients with papillary thyroid cancer, and follow-up of these patients is a matter of debate. Neck ultrasonography (US), serum thyroglobulin (Tg), and whole body scan (WBS) after T(4) withdrawal were performed in 456 patients, followed up to 5 yr. At the end of the first year, 335 patients were Tg negative, and 121 were Tg positive; 65 of 96 patients with Tg levels between 1 and 10 ng/ml became spontaneously Tg negative after 2 yr. During follow-up, WBS discovered node metastases in 13 subjects, and US discovered node metastases in 38 subjects (31 Tg positive and 7 Tg negative). WBS did not add any information, because all WBS-positive patients were also US and Tg positive. Fifty percent of metastases were less than 1 cm and not palpable. Finally, the negative predictive value of both negative Tg and US at first follow-up was 98.8%. We suggest a first follow-up based upon US assessment and stimulated (after T(4) withdrawal or recombinant human TSH) serum Tg determination; subsequently, 1) US should not be mandatory at each examination in initially Tg- and US-negative subjects, but is strongly suggested in all other cases; 2) Tg determination should be repeated 1 yr later, after exogenous or endogenous TSH stimulation only in initially Tg-positive patients without any other evidence of residual disease; and 3) Tg measurement during therapy should be sufficient in all other cases.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0021-972X
|
| pubmed:author |
pubmed-author:ArturiFrancoF,
pubmed-author:AttardMarcoM,
pubmed-author:BrunoRoccoR,
pubmed-author:CostanteGiuseppeG,
pubmed-author:CrocettiUmbertoU,
pubmed-author:D'AzzòGirolamoG,
pubmed-author:FerrettiElisabettaE,
pubmed-author:FilettiSebastianoS,
pubmed-author:MeringoloDomenicoD,
pubmed-author:SaccoRosarioR,
pubmed-author:TorlontanoMassimoM,
pubmed-author:TuminoSalvatoreS
|
| pubmed:issnType |
Print
|
| pubmed:volume |
89
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3402-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15240622-Adolescent,
pubmed-meshheading:15240622-Adult,
pubmed-meshheading:15240622-Biopsy,
pubmed-meshheading:15240622-Carcinoma, Papillary,
pubmed-meshheading:15240622-Cohort Studies,
pubmed-meshheading:15240622-Drug Administration Schedule,
pubmed-meshheading:15240622-Female,
pubmed-meshheading:15240622-Follow-Up Studies,
pubmed-meshheading:15240622-Humans,
pubmed-meshheading:15240622-Iodine Radioisotopes,
pubmed-meshheading:15240622-Lymph Nodes,
pubmed-meshheading:15240622-Lymphatic Metastasis,
pubmed-meshheading:15240622-Male,
pubmed-meshheading:15240622-Neck,
pubmed-meshheading:15240622-Neoplasm Recurrence, Local,
pubmed-meshheading:15240622-Predictive Value of Tests,
pubmed-meshheading:15240622-Risk Factors,
pubmed-meshheading:15240622-Sensitivity and Specificity,
pubmed-meshheading:15240622-Thyroglobulin,
pubmed-meshheading:15240622-Thyroid Neoplasms,
pubmed-meshheading:15240622-Thyroxine
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Follow-up of low risk patients with papillary thyroid cancer: role of neck ultrasonography in detecting lymph node metastases.
|
| pubmed:affiliation |
Unit of Endocrinology, Scientific Institute Casa Sollievo della Sofferanza, 71013 S. Giovanni Rotondo, Foggia, Italy.
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|