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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0018270,
umls-concept:C0030705,
umls-concept:C0042769,
umls-concept:C0085295,
umls-concept:C0220847,
umls-concept:C0524910,
umls-concept:C0682076,
umls-concept:C1456820,
umls-concept:C1510411,
umls-concept:C1882417
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pubmed:issue |
4
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pubmed:dateCreated |
2004-4-21
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pubmed:abstractText |
Ethnic differences in the outcome of hepatitis C have been described. Our aim was to investigate ethnic differences in the distribution of genotypes associated with polymorphisms of the tumor necrosis factor-alpha promoter, interleukin-10 promoter, and transforming growth factor-beta1 leader sequence in patients with hepatitis C. Genomic DNA was obtained from 71 Egyptians and 67 Caucasians (hepatitis C and control patients). Amplification of appropriate gene segments was followed by direct sequencing. Infrequently occurring polymorphisms were identified at positions -244 and -77 of the tumor necrosis factor-alpha promoter and at positions -851 and -657 of the interleukin-10 promoter. The G/A genotype associated with tumor necrosis factor-alpha promoter positions -376 and -244 was more frequent in Egyptians (P =0.001 and P =0.004, respectively). The -244 G/A genotype occurred only in healthy Egyptians (P =0.024). Thus, ethnic differences in the distribution of genotypes of the tumor necrosis factor-alpha promoter exist, which may have clinical implications on the outcome of hepatitis C.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0002-9637
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
434-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15100460-Adult,
pubmed-meshheading:15100460-Base Sequence,
pubmed-meshheading:15100460-DNA,
pubmed-meshheading:15100460-Egypt,
pubmed-meshheading:15100460-Female,
pubmed-meshheading:15100460-Genetic Predisposition to Disease,
pubmed-meshheading:15100460-Hepacivirus,
pubmed-meshheading:15100460-Hepatitis C, Chronic,
pubmed-meshheading:15100460-Humans,
pubmed-meshheading:15100460-Interleukin-10,
pubmed-meshheading:15100460-Liver,
pubmed-meshheading:15100460-Male,
pubmed-meshheading:15100460-Middle Aged,
pubmed-meshheading:15100460-Minnesota,
pubmed-meshheading:15100460-Molecular Sequence Data,
pubmed-meshheading:15100460-Polymerase Chain Reaction,
pubmed-meshheading:15100460-Polymorphism, Genetic,
pubmed-meshheading:15100460-Polymorphism, Single Nucleotide,
pubmed-meshheading:15100460-Retrospective Studies,
pubmed-meshheading:15100460-Sequence Analysis, DNA,
pubmed-meshheading:15100460-Transforming Growth Factor beta,
pubmed-meshheading:15100460-Transforming Growth Factor beta1,
pubmed-meshheading:15100460-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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pubmed:articleTitle |
Ethnic differences in polymorphisms of tumor necrosis factor-alpha, interleukin-10, and transforming growth factor-beta1 genes in patients with chronic hepatitis C virus infection.
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pubmed:affiliation |
Division of Gastroenterology, Hepatology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA. zeinn@ccf.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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