Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2004-4-6
pubmed:abstractText
Lupus-prone New Zealand Black and New Zealand White mice produce high serum levels of the endogenous retroviral envelope protein gp70 and develop an Ab response to this autoantigen as part of their autoimmune disease. Linkage analysis of two crosses involving New Zealand and BALB/c mice mapped these traits to a group of overlapping loci, including a novel locus on proximal chromosome 12. This locus was linked with serum gp70 and the autoimmune response against it. The linkage of serum gp70 levels to a previously described locus on distal chromosome 4 was also confirmed. Sequence analysis of a candidate gene on distal chromosome 4, Fv1, provided support that this gene may be associated with the control of serum gp70 levels in both New Zealand Black and New Zealand White mice. Linkage data and statistical analysis confirmed a close correlation between gp70 Ag and anti-gp70 Ab levels, and together gave support to the concept that a threshold level of gp70 is required for the production of anti-gp70 Abs. Serum levels of anti-gp70 Abs were closely correlated with the presence of renal disease, more so than anti-dsDNA Abs. Understanding the genetic basis of this complex autoantigen-autoantibody system will provide insight into the pathogenesis of lupus in mice, which may have implications for human disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
172
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5078-85
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:15067091-Animals, pubmed-meshheading:15067091-Antibodies, Viral, pubmed-meshheading:15067091-Chromosome Mapping, pubmed-meshheading:15067091-Crosses, Genetic, pubmed-meshheading:15067091-Female, pubmed-meshheading:15067091-Gene Expression Regulation, pubmed-meshheading:15067091-Genetic Linkage, pubmed-meshheading:15067091-Genetic Markers, pubmed-meshheading:15067091-Genetic Predisposition to Disease, pubmed-meshheading:15067091-Glomerulonephritis, pubmed-meshheading:15067091-Glycoproteins, pubmed-meshheading:15067091-Mice, pubmed-meshheading:15067091-Mice, Congenic, pubmed-meshheading:15067091-Mice, Inbred BALB C, pubmed-meshheading:15067091-Mice, Inbred NZB, pubmed-meshheading:15067091-Proteins, pubmed-meshheading:15067091-Retroviridae, pubmed-meshheading:15067091-Species Specificity, pubmed-meshheading:15067091-Viral Envelope Proteins
pubmed:year
2004
pubmed:articleTitle
A novel locus regulates both retroviral glycoprotein 70 and anti-glycoprotein 70 antibody production in New Zealand mice when crossed with BALB/c.
pubmed:affiliation
Rheumatology Section, Imperial College Faculty of Medicine, Hammersmith Campus, London, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't