Linked Life Data

15042514

Source:http://linkedlifedata.com/resource/pubmed/id/15042514

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-3-25
pubmed:abstractText
Peripheral nerve injury is associated with hyperesthesia and increased neurokinin-1 receptor (NK-1) expression in the dorsal horn of the spinal cord. To test the hypothesis that NK-1 gene expression underlies these responses, we used solution hybridization-nuclease protection assays to quantify NK-1 mRNA levels in dorsal quadrants of the mouse lumbar dorsal horn. Partial sciatic nerve ligation was associated with mechanical allodynia, thermal hyperalgesia, and an increase in NK-1 mRNA on the ipsilateral, but not contralateral, side. Regression analysis showed that NK-1 mRNA was significantly correlated with thermal paw withdrawal latency but not mechanical threshold. Our results support the idea that substance P is an important mediator of thermal hypersensitivity in the setting of nerve injury and suggest that increased NK-1 receptor transcription precedes increased NK-1 receptor density, ultimately leading to behavioral hypersensitivity to peripheral thermal stimulation. PERSPECTIVE: The therapeutic efficacy of NK-1 receptor antagonists is unclear. The current data suggest that peripheral nerve injury increases the expression of substance P (NK-1) receptors in the spinal cord dorsal horn; this is correlated with heat hypersensitivity. The analgesic effects of NK-1 antagonists might become apparent if tested against heat-evoked pain in nerve injury patients.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1526-5900
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Neurokinin-1 receptor gene expression in the mouse dorsal horn increases with neuropathic pain.
pubmed:affiliation
Deparment of Pharmacology, Tulane University Health Sciences Center, New Orleans, LA 70018, USA. taylorb@tulane.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.