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rdf:type |
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lifeskim:mentions |
umls-concept:C0013138,
umls-concept:C0017337,
umls-concept:C0031760,
umls-concept:C0033684,
umls-concept:C0679058,
umls-concept:C1292733,
umls-concept:C1514562,
umls-concept:C1547699,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C2700640
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pubmed:issue |
15
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pubmed:dateCreated |
1992-9-4
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pubmed:databankReference |
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pubmed:abstractText |
Studies on sevenless and bride of sevenless genes have revealed that the R8 cell plays a key role in the fate of the R7 photoreceptor cell, presenting on its surface an inductive cue to which R7 responds. sev-independent induction of R7 cells has been reported in the seven-up mutation, which appears to transform R1 and R6 cells to R7 cells. We have induced recessive mutations in a gene pokkuri (pok; pokkuri is a Japanese word that means "dropping dead") that lead to overproduction of R7 cells with rather minor effects on outer photoreceptors and R8 cells. Pok protein may function as a transcription factor, as the predicted amino acid sequence contains a region similar to the consensus established for the E-26-specific (Ets) domain.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495974-16453599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495974-17985474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495974-1857416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495974-1876836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495974-2004416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495974-2105166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495974-2140105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495974-2146028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495974-2253872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495974-2830671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495974-3119227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495974-3167983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1495974-4942064
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ERF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ETS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Protein c-ets-2,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ets,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6856-60
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1495974-Amino Acid Sequence,
pubmed-meshheading:1495974-Animals,
pubmed-meshheading:1495974-Base Sequence,
pubmed-meshheading:1495974-Crosses, Genetic,
pubmed-meshheading:1495974-DNA-Binding Proteins,
pubmed-meshheading:1495974-Drosophila,
pubmed-meshheading:1495974-Eye Proteins,
pubmed-meshheading:1495974-Female,
pubmed-meshheading:1495974-Genes,
pubmed-meshheading:1495974-Genotype,
pubmed-meshheading:1495974-Heterozygote Detection,
pubmed-meshheading:1495974-Homozygote,
pubmed-meshheading:1495974-Humans,
pubmed-meshheading:1495974-Male,
pubmed-meshheading:1495974-Molecular Sequence Data,
pubmed-meshheading:1495974-Mosaicism,
pubmed-meshheading:1495974-Photoreceptor Cells,
pubmed-meshheading:1495974-Protein-Tyrosine Kinases,
pubmed-meshheading:1495974-Proto-Oncogene Protein c-ets-2,
pubmed-meshheading:1495974-Proto-Oncogene Proteins,
pubmed-meshheading:1495974-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:1495974-Proto-Oncogenes,
pubmed-meshheading:1495974-Repressor Proteins,
pubmed-meshheading:1495974-Restriction Mapping,
pubmed-meshheading:1495974-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1495974-Trans-Activators,
pubmed-meshheading:1495974-Transcription Factors
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pubmed:year |
1992
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pubmed:articleTitle |
pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor.
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pubmed:affiliation |
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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