Source:http://linkedlifedata.com/resource/pubmed/id/14692523
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2003-12-24
|
| pubmed:abstractText |
Association between certain surface markers and acute myelogenous leukemia (AML) with t(8;21) has been described. The specificity and the predictive values of these markers have never been assessed. In this study, we aimed, to explore whether a specific pattern could predict for this translocation. Of 405 consecutive AML, 18 (4.4%) had the t(8;21). Patients with this cytogenetic abnormality showed higher frequency of CD34 (P = 0.003), HLA-DR (P = 0.03), Tdt (P = 0.02), CD19 (P < 0.0001), and CD56 (P < 0.0001) and lower CD33 (P = 0.0001). Taken singly, the sensitivity of these markers for AML with t(8;21) ranged between 39 and 100% with CD34+ having the highest and CD33- having the lowest and the positive predictive values (PPV) ranged between 5 and 21% with CD19+ having the highest and HLA-DR+ having the lowest. When combinations of different markers were analyzed by multivariate analysis, the pattern CD34+/HLA-DR+/MPO+ was found to have the highest sensitivity (100%) with a PPV of 14% and the pattern CD34+/CD19+/CD56+ had the highest PPV (100%) with a sensitivity of 67%. We conclude that AML with t(8;21) is better identified by a combination of markers than by a single antigen pattern, the absence of CD34+, HLA-DR+ or MPO+ would preclude and the expression of the pattern CD34+/CD19+/CD56+ is highly predictive and could serve as a screening criteria for the t(8;21).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1042-8194
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| pubmed:author |
pubmed-author:BarnettMichael JMJ,
pubmed-author:ConneallyEbhilin AEA,
pubmed-author:DalalBakul IBI,
pubmed-author:HoggeDonna EDE,
pubmed-author:HorsmanDouglas EDE,
pubmed-author:KhouryHaythamH,
pubmed-author:NantelStephen HSH,
pubmed-author:NevillThomas JTJ,
pubmed-author:ShepherdJohn DJD,
pubmed-author:SutherlandHeather JHJ,
pubmed-author:TozeCindy LCL
|
| pubmed:issnType |
Print
|
| pubmed:volume |
44
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1713-8
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:14692523-Adolescent,
pubmed-meshheading:14692523-Adult,
pubmed-meshheading:14692523-Aged,
pubmed-meshheading:14692523-Antigens, CD,
pubmed-meshheading:14692523-Case-Control Studies,
pubmed-meshheading:14692523-Chromosomes, Human, Pair 21,
pubmed-meshheading:14692523-Chromosomes, Human, Pair 8,
pubmed-meshheading:14692523-DNA Nucleotidylexotransferase,
pubmed-meshheading:14692523-Female,
pubmed-meshheading:14692523-Flow Cytometry,
pubmed-meshheading:14692523-Gene Expression Regulation, Leukemic,
pubmed-meshheading:14692523-HLA-DR Antigens,
pubmed-meshheading:14692523-Humans,
pubmed-meshheading:14692523-Immunophenotyping,
pubmed-meshheading:14692523-Karyotyping,
pubmed-meshheading:14692523-Leukemia, Myeloid, Acute,
pubmed-meshheading:14692523-Male,
pubmed-meshheading:14692523-Middle Aged,
pubmed-meshheading:14692523-Translocation, Genetic
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Acute myelogenous leukemia with t(8;21)--identification of a specific immunophenotype.
|
| pubmed:affiliation |
Leukemia/BMT Program of British Columbia, Vancouver, Canada. khaytham@uhnres.utoronto.ca
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|