Linked Life Data

14639613

Source:http://linkedlifedata.com/resource/pubmed/id/14639613

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-11-25
pubmed:abstractText
Conditions related to chronic hyperinsulinemia, such as obesity, noninsulin dependent diabetes mellitus and polycystic ovary syndrome, are associated with an increased risk of endometrial cancer. Elevated plasma IGF-I and decreased levels of IGF-binding proteins have been shown to be associated with increased risk of several cancer types that are frequent in affluent societies. We investigated for the first time in a prospective study the association of pre-diagnostic blood concentrations of C-peptide (a marker of pancreatic insulin production), IGF-I, IGFBP-1, -2 and -3 with endometrial cancer risk. A case-control study was nested within 3 cohorts in New York (USA), Umeå (Sweden) and Milan (Italy). It included 166 women with primary invasive endometrial cancer and 315 matched controls, of which 44 case and 78 control subjects were premenopausal at recruitment. Endometrial cancer risk increased with increasing levels of C-peptide (ptrend = 0.0002), up to an odds ratio (OR) of 4.76 [95% confidence interval (CI) = 1.91-11.8] for the highest quintile. This association remained after adjustment for BMI and other confounders [OR for the top quintile = 4.40 (1.65-11.7)]. IGFBP-1 levels were inversely related to endometrial cancer [ptrend = 0.002; OR in the upper quintile = 0.30 (0.15-0.62)], but the association was weakened and lost statistical significance after adjustment for confounders [ptrend = 0.06; OR in the upper quintile = 0.49 (0.22-1.07)]. Risk was unrelated to levels of IGF-I, IGFBP-2 and IGFBP-3. Chronic hyperinsulinemia, as reflected by increased circulating C-peptide, is associated with increased endometrial cancer risk. Decrease in the prevalence of chronic hyperinsulinemia, through changes in lifestyle or medication, is expected to prevent endometrial cancer.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0020-7136
pubmed:author
pubmed:copyrightInfo
Copyright 2003 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
262-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:14639613-Adult, pubmed-meshheading:14639613-Aged, pubmed-meshheading:14639613-C-Peptide, pubmed-meshheading:14639613-Case-Control Studies, pubmed-meshheading:14639613-Chronic Disease, pubmed-meshheading:14639613-Cohort Studies, pubmed-meshheading:14639613-Endometrial Neoplasms, pubmed-meshheading:14639613-Female, pubmed-meshheading:14639613-Humans, pubmed-meshheading:14639613-Hyperinsulinism, pubmed-meshheading:14639613-Insulin, pubmed-meshheading:14639613-Insulin-Like Growth Factor Binding Protein 1, pubmed-meshheading:14639613-Insulin-Like Growth Factor Binding Protein 2, pubmed-meshheading:14639613-Insulin-Like Growth Factor Binding Protein 3, pubmed-meshheading:14639613-Insulin-Like Growth Factor I, pubmed-meshheading:14639613-Middle Aged, pubmed-meshheading:14639613-Prognosis, pubmed-meshheading:14639613-Prospective Studies, pubmed-meshheading:14639613-Risk Factors, pubmed-meshheading:14639613-Tumor Markers, Biological
pubmed:year
2004
pubmed:articleTitle
Prediagnostic levels of C-peptide, IGF-I, IGFBP -1, -2 and -3 and risk of endometrial cancer.
pubmed:affiliation
International Agency for Research on Cancer, Lyon, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Multicenter Study