|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1992-12-11
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
We have identified a human homolog of the Drosophila trithorax protein that is structurally altered by 11q23 translocations in acute leukemias. Human trithorax (HRX) is a predicted 431 kd protein containing two potential DNA-binding motifs consisting of zinc fingers conserved with the fly protein and nonconserved amino-terminal "AT hook" motifs related to the DNA-binding motifs in HMG proteins. 11q23 translocations disrupt the HRX gene between these two motifs, and in a t(11;19)-carrying cell line fusion transcripts are expressed from both derivative chromosomes. The more abundant derivative 11 transcript codes for a chimeric protein containing the AT hook motifs fused to a previously undescribed protein (ENL) from chromosome 19. These data suggest a novel role for a trithorax-homologous protein in multilineage human leukemias that may be mediated by DNA binding within the minor groove at AT-rich sites, implicated to play an important role in bacterial IHF-, yeast datin-, and mammalian HMG-mediated gene activation.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0092-8674
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
13
|
|
pubmed:volume |
71
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
691-700
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:1423624-Acute Disease,
pubmed-meshheading:1423624-Amino Acid Sequence,
pubmed-meshheading:1423624-Animals,
pubmed-meshheading:1423624-Base Sequence,
pubmed-meshheading:1423624-Chromosomes, Human, Pair 11,
pubmed-meshheading:1423624-Chromosomes, Human, Pair 19,
pubmed-meshheading:1423624-DNA-Binding Proteins,
pubmed-meshheading:1423624-Drosophila,
pubmed-meshheading:1423624-Drosophila Proteins,
pubmed-meshheading:1423624-Gene Expression Regulation, Leukemic,
pubmed-meshheading:1423624-Humans,
pubmed-meshheading:1423624-Leukemia,
pubmed-meshheading:1423624-Molecular Sequence Data,
pubmed-meshheading:1423624-Myeloid-Lymphoid Leukemia Protein,
pubmed-meshheading:1423624-Proto-Oncogenes,
pubmed-meshheading:1423624-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1423624-Transcription Factors,
pubmed-meshheading:1423624-Transcriptional Activation,
pubmed-meshheading:1423624-Translocation, Genetic,
pubmed-meshheading:1423624-Zinc Fingers
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias.
|
|
pubmed:affiliation |
Department of Pathology, Stanford University School of Medicine, California 94305.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
