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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6375
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pubmed:dateCreated |
1992-6-19
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pubmed:databankReference |
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pubmed:abstractText |
Short antigenic peptides bound in the groove of class I major histocompatibility complex molecules enable T cells to detect intracellular pathogens. It has been assumed that structural features of the class I molecule alone select which peptides are bound. It is now demonstrated that a complex polymorphism in one of the major histocompatibility complex-encoded putative peptide-transporter genes is associated with an altered spectrum of bound peptides.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
357
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pubmed:geneSymbol |
RT1.A,
cim,
mtp2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
211-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1350326-Alleles,
pubmed-meshheading:1350326-Amino Acid Sequence,
pubmed-meshheading:1350326-Animals,
pubmed-meshheading:1350326-Carrier Proteins,
pubmed-meshheading:1350326-Cell Line,
pubmed-meshheading:1350326-Genes, MHC Class I,
pubmed-meshheading:1350326-Histocompatibility Antigens Class I,
pubmed-meshheading:1350326-Humans,
pubmed-meshheading:1350326-Kinetics,
pubmed-meshheading:1350326-Lymphoma, T-Cell,
pubmed-meshheading:1350326-Major Histocompatibility Complex,
pubmed-meshheading:1350326-Membrane Proteins,
pubmed-meshheading:1350326-Membrane Transport Proteins,
pubmed-meshheading:1350326-Molecular Sequence Data,
pubmed-meshheading:1350326-Poly A,
pubmed-meshheading:1350326-Polymerase Chain Reaction,
pubmed-meshheading:1350326-Polymorphism, Genetic,
pubmed-meshheading:1350326-Protein Conformation,
pubmed-meshheading:1350326-RNA, Messenger,
pubmed-meshheading:1350326-Rats,
pubmed-meshheading:1350326-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1350326-Transfection
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pubmed:year |
1992
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pubmed:articleTitle |
Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule.
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pubmed:affiliation |
Department of Immunology, Agricultural and Food Research Council Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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