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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
16
|
| pubmed:dateCreated |
1992-9-10
|
| pubmed:abstractText |
Cancer cells elaborate metalloproteinases which may play a role in invasion and metastasis. The serum level of the M(r) 72,000 type IV collagenase (MMP-2) was measured in 87 lung cancer patients. Stage IV cancer levels were significantly elevated (P less than 0.0001) compared to normal sera. A significant difference (P less than 0.01) was found between enzyme levels in the presence versus the absence of distant metastasis. For 29 patients treated with combination chemotherapy, a positive relationship was noted between response failure and elevated enzyme levels. Serum metalloproteinase levels may provide information relevant to prognosis as well as treatment decisions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0008-5472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
52
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4548-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1322794-Carcinoma, Small Cell,
pubmed-meshheading:1322794-Humans,
pubmed-meshheading:1322794-Lung Neoplasms,
pubmed-meshheading:1322794-Matrix Metalloproteinase 9,
pubmed-meshheading:1322794-Microbial Collagenase,
pubmed-meshheading:1322794-Neoplasm Metastasis,
pubmed-meshheading:1322794-Tumor Markers, Biological
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy.
|
| pubmed:affiliation |
Histology Institute, Padova University, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|