| pubmed-article:12907645 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12907645 | lifeskim:mentions | umls-concept:C0042071 | lld:lifeskim |
| pubmed-article:12907645 | lifeskim:mentions | umls-concept:C0024623 | lld:lifeskim |
| pubmed-article:12907645 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:12907645 | lifeskim:mentions | umls-concept:C0668195 | lld:lifeskim |
| pubmed-article:12907645 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12907645 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:12907645 | pubmed:dateCreated | 2003-8-8 | lld:pubmed |
| pubmed-article:12907645 | pubmed:abstractText | In our search for genes associated with gastric cancer progression, we identified macrophage inhibitory cytokine-1 (MIC-1), a member of the transforming growth factor beta superfamily, as an overexpressed gene in gastric tumor tissues. Expression analysis of MIC-1 in gastric tumor tissues revealed a specific expression in gastric cancer cells, and this expression level was well correlated with invasive potential in various human gastric cancer cell lines. Stable transfection of MIC-1 into SNU-216, a human gastric cancer cell line, significantly increased its invasiveness. The overexpression of MIC-1 into SNU-216 cells significantly increased the activity of urokinase-type plasminogen activator (uPA), and the expressions of uPA and urokinase-type plasminogen activator receptor (uPAR). Similarly, the stimulation of gastric cancer cell lines with purified recombinant MIC-1 dose-dependently increased cell invasiveness, uPA activity, and uPA and uPAR expression. However, MIC-1 did not significantly suppress the proliferation of gastric cancer cell lines. We also found that the stimulation of human gastric cell lines with recombinant MIC-1 strongly induced activation of mitogen-activated protein kinase kinase-1/2 and extracellular signal-regulated kinase-1/2. Additional analysis revealed that PD98059, a selective inhibitor of mitogen-activated protein kinase kinase-1/2, suppressed not only gastric cancer cell invasiveness and uPA activity, but also the mRNA expressions of uPA and uPAR, as induced by recombinant MIC-1. Our results indicate that MIC-1 may contribute to the malignant progression of gastric cancer cells by inducing tumor cell invasion through the up-regulation of the uPA activation system via extracellular signal-regulated kinase-1/2-dependent pathway. | lld:pubmed |
| pubmed-article:12907645 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12907645 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12907645 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12907645 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12907645 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12907645 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:12907645 | pubmed:author | pubmed-author:LeeJung... | lld:pubmed |
| pubmed-article:12907645 | pubmed:author | pubmed-author:LeeYoung HoYH | lld:pubmed |
| pubmed-article:12907645 | pubmed:author | pubmed-author:LeeJeong-Hyun... | lld:pubmed |
| pubmed-article:12907645 | pubmed:author | pubmed-author:KooTae... | lld:pubmed |
| pubmed-article:12907645 | pubmed:author | pubmed-author:KimYung-JinYJ | lld:pubmed |
| pubmed-article:12907645 | pubmed:author | pubmed-author:YangYoungY | lld:pubmed |
| pubmed-article:12907645 | pubmed:author | pubmed-author:ShinSun MiSM | lld:pubmed |
| pubmed-article:12907645 | pubmed:author | pubmed-author:ChoiInpyoI | lld:pubmed |
| pubmed-article:12907645 | pubmed:author | pubmed-author:LeeDong... | lld:pubmed |
| pubmed-article:12907645 | pubmed:author | pubmed-author:SongKyu... | lld:pubmed |
| pubmed-article:12907645 | pubmed:author | pubmed-author:LeeSoon... | lld:pubmed |
| pubmed-article:12907645 | pubmed:author | pubmed-author:KimKun-YongKY | lld:pubmed |
| pubmed-article:12907645 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12907645 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12907645 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:12907645 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12907645 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12907645 | pubmed:pagination | 4648-55 | lld:pubmed |
| pubmed-article:12907645 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12907645 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12907645 | pubmed:articleTitle | Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system. | lld:pubmed |
| pubmed-article:12907645 | pubmed:affiliation | Laboratories of Anticancer Research, Korea Research Institute of Bioscience and Biotechnology, Yusung, Daejon 305-333, Republic of Korea. | lld:pubmed |
| pubmed-article:12907645 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12907645 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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