Source:http://linkedlifedata.com/resource/umls/id/C0668195
MSH: A growth differentiation factor that is secreted in response to cell stress and in response to MACROPHAGE ACTIVATION. In addition growth differentiation factor 15 demonstrates a diverse array of biological properties including the induction of cartilage formation, the inhibition of hematopoietic progenitor proliferation, and the induction of neuronal migration.,NCI: Expressed in activated, but not resting, macrophages and in placenta, prostate, colon, and kidney by human PLAB Gene (BMP/TGF-Beta Family), 308-aa 34-kDa (precursor) Placental TGF-Beta is processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in a disulfide-linked homodimeric secreted mature protein of 224 amino acids. PLAB regulates tissue differentiation and maintenance and reduces the growth of granulocytes and macrophages. Unlike most TGFB superfamily members, in which the amino acid sequence is completely conserved, PLAB shares only 70% amino acid identity with its ro