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rdf:type |
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lifeskim:mentions |
umls-concept:C0021665,
umls-concept:C0033414,
umls-concept:C0038952,
umls-concept:C0083867,
umls-concept:C0086418,
umls-concept:C0205195,
umls-concept:C0205217,
umls-concept:C0205307,
umls-concept:C0220781,
umls-concept:C0225369,
umls-concept:C0331858,
umls-concept:C0521339,
umls-concept:C1332428,
umls-concept:C1704640,
umls-concept:C1706515,
umls-concept:C1883254
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pubmed:issue |
8
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pubmed:dateCreated |
2003-8-7
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pubmed:abstractText |
Although growth factor therapy could be an attractive method for stimulating the repair of damaged cartilage matrix, there is evidence that with aging and/or with the development of osteoarthritis (OA), articular chondrocytes may become unresponsive to growth factor stimulation. The aim of the current study was to compare the ability of insulin-like growth factor+(IGF-1) and osteogenic protein+(OP-1), alone and in combination, to stimulate human normal and OA chondrocytes in culture.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alginates,
http://linkedlifedata.com/resource/pubmed/chemical/BMP7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 7,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Hexuronic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/alginic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2188-96
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12905472-Adult,
pubmed-meshheading:12905472-Aged,
pubmed-meshheading:12905472-Alginates,
pubmed-meshheading:12905472-Bone Morphogenetic Protein 7,
pubmed-meshheading:12905472-Bone Morphogenetic Proteins,
pubmed-meshheading:12905472-Cartilage, Articular,
pubmed-meshheading:12905472-Cell Culture Techniques,
pubmed-meshheading:12905472-Cell Differentiation,
pubmed-meshheading:12905472-Cell Division,
pubmed-meshheading:12905472-Cell Survival,
pubmed-meshheading:12905472-Cells, Cultured,
pubmed-meshheading:12905472-Chondrocytes,
pubmed-meshheading:12905472-DNA,
pubmed-meshheading:12905472-Extracellular Matrix,
pubmed-meshheading:12905472-Glucuronic Acid,
pubmed-meshheading:12905472-Hexuronic Acids,
pubmed-meshheading:12905472-Humans,
pubmed-meshheading:12905472-Insulin-Like Growth Factor I,
pubmed-meshheading:12905472-Middle Aged,
pubmed-meshheading:12905472-Osteoarthritis,
pubmed-meshheading:12905472-Proteoglycans,
pubmed-meshheading:12905472-Transforming Growth Factor beta
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pubmed:year |
2003
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pubmed:articleTitle |
The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes.
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pubmed:affiliation |
Rheumatology, Rush Medical College of Rush-Presbyterian-St. Luke's Medical Center, 1725 West Harrison, Suite 1017, Chicago, IL 60612, USA. rloeser@rush.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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