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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-7-28
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pubmed:abstractText |
Pancreatic fibrosis is a characteristic feature of alcoholic chronic pancreatitis. Recent studies suggest that activated pancreatic stellate cells (PSCs) are the major cell-type involved in pancreatic fibrogenesis. Cultured PSCs become activated when exposed to ethanol or its metabolite acetaldehyde (as indicated by increased alpha-smooth muscle actin [alpha-SMA] expression and increased collagen synthesis). However the intracellular signaling mechanisms responsible for ethanol- or acetaldehyde-induced PSC activation remain to be fully elucidated. One of the major signaling pathways known to regulate protein synthesis in mammalian cells is the mitogen-activated protein kinase (MARK) pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetaldehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/SB 203580,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1536-4828
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
150-60
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12883264-Acetaldehyde,
pubmed-meshheading:12883264-Actins,
pubmed-meshheading:12883264-Animals,
pubmed-meshheading:12883264-Cells, Cultured,
pubmed-meshheading:12883264-Enzyme Activation,
pubmed-meshheading:12883264-Enzyme Inhibitors,
pubmed-meshheading:12883264-Imidazoles,
pubmed-meshheading:12883264-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:12883264-MAP Kinase Signaling System,
pubmed-meshheading:12883264-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:12883264-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:12883264-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12883264-Muscle, Smooth,
pubmed-meshheading:12883264-Pancreas,
pubmed-meshheading:12883264-Protein Kinase Inhibitors,
pubmed-meshheading:12883264-Protein Kinases,
pubmed-meshheading:12883264-Pyridines,
pubmed-meshheading:12883264-Rats,
pubmed-meshheading:12883264-Time Factors,
pubmed-meshheading:12883264-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2003
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pubmed:articleTitle |
Pancreatic stellate cell activation by ethanol and acetaldehyde: is it mediated by the mitogen-activated protein kinase signaling pathway?
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pubmed:affiliation |
Pancreatic Research Group, The University of New South Wales, Sydney, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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