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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-6-9
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pubmed:abstractText |
Although chimeric EWS gene and Ets gene fusions are pathognomonic of Ewing sarcoma (ES) and primitive neuroectodermal tumors (PNET), the molecular pathogenesis of these pediatric malignancies is poorly understood. Recently, the human epidermal growth factor (HER)-2 receptor, which plays an important role in the biology of certain epithelial cancers, has been implicated in ES tumor cell line growth and chemosensitivity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1077-4114
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
459-66
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12794524-Antibodies, Monoclonal,
pubmed-meshheading:12794524-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:12794524-Blotting, Western,
pubmed-meshheading:12794524-Bone Neoplasms,
pubmed-meshheading:12794524-Cell Survival,
pubmed-meshheading:12794524-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12794524-Humans,
pubmed-meshheading:12794524-Immunoenzyme Techniques,
pubmed-meshheading:12794524-In Situ Hybridization, Fluorescence,
pubmed-meshheading:12794524-Receptor, erbB-2,
pubmed-meshheading:12794524-Sarcoma, Ewing,
pubmed-meshheading:12794524-Tumor Cells, Cultured
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pubmed:year |
2003
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pubmed:articleTitle |
The epidermal growth factor receptor HER2 is not a major therapeutic target in Ewing sarcoma.
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pubmed:affiliation |
Division of Hematology/Oncology and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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