Linked Life Data

12734353

Source:http://linkedlifedata.com/resource/pubmed/id/12734353

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2003-5-7
pubmed:abstractText
Inhibition of TNF/TNFR2 interactions ameliorates intestinal graft-vs-host disease (GVHD) and Th1 cytokine responses induced by transfer of B6 CD4(+) spleen cells into irradiated MHC class II disparate B6.C-H-2(bm12) (bm12) x B6 F(1) recipients. The present studies examined whether these effects of TNF are IL-12 dependent. T cell proliferative responses of B6.129S1-IL-12rb2(tm1Jm) (B6.IL-12R(-/-)) responder spleen cells were found to be comparable to those of control B6 spleen cells. TNF inhibition reduced T cell proliferation and IFN-gamma production in supernatants of MLC using either B6.IL-12R(-/-) or control B6 responder cells. GVHD induced wasting disease in recipients of B6.IL-12R(-/-) CD4(+) spleen cells that received a TNF inhibitor-encoding adenovirus (5.4 +/- 6.5% weight loss (n = 7)) was significantly reduced compared with levels of weight loss observed in recipients that had received a control adenovirus (25.7 +/- 12.2% weight loss (n = 11), p = 0.001). Furthermore, TNF inhibition was associated with a reduction in colonic GVHD scores (p = 0.039) and in the percentage of the splenic CD4(+) T cells that expressed IFN-gamma (16 vs 6%). These findings indicate that TNF promotes CD4(+) T cell alloproliferation, IFN-gamma responses, and intestinal GVHD by IL-12-independent mechanisms.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
170
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5082-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12734353-Animals, pubmed-meshheading:12734353-Bone Marrow Transplantation, pubmed-meshheading:12734353-CD4-Positive T-Lymphocytes, pubmed-meshheading:12734353-Cells, Cultured, pubmed-meshheading:12734353-Colonic Diseases, pubmed-meshheading:12734353-Down-Regulation, pubmed-meshheading:12734353-Female, pubmed-meshheading:12734353-Graft vs Host Disease, pubmed-meshheading:12734353-Histocompatibility Antigens Class II, pubmed-meshheading:12734353-Humans, pubmed-meshheading:12734353-Immunoglobulin Heavy Chains, pubmed-meshheading:12734353-Interferon-gamma, pubmed-meshheading:12734353-Interleukin-12, pubmed-meshheading:12734353-Interleukin-18, pubmed-meshheading:12734353-Lymphocyte Activation, pubmed-meshheading:12734353-Lymphocyte Culture Test, Mixed, pubmed-meshheading:12734353-Male, pubmed-meshheading:12734353-Mice, pubmed-meshheading:12734353-Mice, Inbred C57BL, pubmed-meshheading:12734353-Mice, Mutant Strains, pubmed-meshheading:12734353-Receptors, Interleukin, pubmed-meshheading:12734353-Receptors, Interleukin-12, pubmed-meshheading:12734353-Receptors, Tumor Necrosis Factor, pubmed-meshheading:12734353-Recombinant Fusion Proteins, pubmed-meshheading:12734353-Spleen, pubmed-meshheading:12734353-Tumor Necrosis Factor-alpha
pubmed:year
2003
pubmed:articleTitle
TNF enhances CD4+ T cell alloproliferation, IFN-gamma responses, and intestinal graft-versus-host disease by IL-12-independent mechanisms.
pubmed:affiliation
Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, and Dallas Veterans Affairs Medical Center, Dallas, TX, USA. gbrow1@mednet.swmed.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.