| pubmed-article:12642587 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12642587 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:12642587 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:12642587 | lifeskim:mentions | umls-concept:C0042071 | lld:lifeskim |
| pubmed-article:12642587 | lifeskim:mentions | umls-concept:C0030190 | lld:lifeskim |
| pubmed-article:12642587 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12642587 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:12642587 | pubmed:dateCreated | 2003-5-12 | lld:pubmed |
| pubmed-article:12642587 | pubmed:abstractText | The plasminogen/plasmin system, urokinase-type plasminogen activator (uPA), its receptor (uPAR), and its inhibitor (PAI-1), influence extracellular proteolysis and cell migration in lung injury or neoplasia. In this study, we sought to determine whether tcuPA (two chain uPA) alters expression of its major inhibitor PAI-1 in lung epithelial cells. The expression of PAI-1 was evaluated at the protein and mRNA level by Western blot, immunoprecipitation, and Northern blot analyses. We found that tcuPA treatment enhanced PAI-1 protein and mRNA expression in Beas2B lung epithelial cells in a time- and concentration-dependent manner. The tcuPA-mediated induction of PAI-1 involves post-transcriptional control involving stabilization of PAI-1 mRNA. Inactivation of the catalytic activity of tcuPA had little effect on PAI-1 induction and the activity of the isolated amino-terminal fragment was comparable with full-length single- or two-chain uPA. In contrast, deletion of either the uPA receptor binding growth factor domain or kringle domain (kringle) from full-length single chain uPA markedly attenuated the induction of PAI-1. Induction of PAI-1 by exposure of lung epithelial cells to uPA is a newly recognized pathway by which PAI-1 could regulate local fibrinolysis and urokinase-dependent cellular responses in the setting of lung inflammation or neoplasia. | lld:pubmed |
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| pubmed-article:12642587 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12642587 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12642587 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12642587 | pubmed:month | May | lld:pubmed |
| pubmed-article:12642587 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12642587 | pubmed:author | pubmed-author:CinesDouglas... | lld:pubmed |
| pubmed-article:12642587 | pubmed:author | pubmed-author:BdeirKhalilK | lld:pubmed |
| pubmed-article:12642587 | pubmed:author | pubmed-author:ShettySreeram... | lld:pubmed |
| pubmed-article:12642587 | pubmed:author | pubmed-author:IdellStevenS | lld:pubmed |
| pubmed-article:12642587 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12642587 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:12642587 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:12642587 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12642587 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12642587 | pubmed:pagination | 18124-31 | lld:pubmed |
| pubmed-article:12642587 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12642587 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12642587 | pubmed:articleTitle | Induction of plasminogen activator inhibitor-1 by urokinase in lung epithelial cells. | lld:pubmed |
| pubmed-article:12642587 | pubmed:affiliation | Department of Specialty Care Services, University of Texas Health Center, Tyler, Texas 75708, USA. | lld:pubmed |
| pubmed-article:12642587 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12642587 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12642587 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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