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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1976-7-6
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pubmed:abstractText |
The distribution of digoxin in the myocardium, skeletal muscle, erythrocytes, and plasma (or serum) was studied in 19 infants. There was a linear relationship between myocardium and serum concentrations and no saturation was observed over the serum concentration range of 0.5-8.6 ng/ml. Myocardium uptake of digoxin was nearly twice as great in infants as in adults at any given serum concentration. Erythrocyte: plasma concentration ratios of digoxin were one-third smaller during digitalization than during maintenance digoxin therapy. The latter ratios were also three times greater in infants than found previously in adults. Their findings are consistent with a greater apparent volume of distribution of digoxin in infants and may partly explain the unusually large therapeutic doses needed in infants.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-9236
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
256-63
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1261163-Digoxin,
pubmed-meshheading:1261163-Erythrocytes,
pubmed-meshheading:1261163-Heart Defects, Congenital,
pubmed-meshheading:1261163-Heart Failure,
pubmed-meshheading:1261163-Humans,
pubmed-meshheading:1261163-Infant,
pubmed-meshheading:1261163-Infant, Newborn,
pubmed-meshheading:1261163-Iodine Radioisotopes,
pubmed-meshheading:1261163-Kinetics,
pubmed-meshheading:1261163-Muscles,
pubmed-meshheading:1261163-Myocardium
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pubmed:year |
1976
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pubmed:articleTitle |
Tissue and erythrocyte distribution of digoxin in infants.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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