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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2003-2-4
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|
pubmed:abstractText |
The synthesis and pharmacological activity of novel nociceptin/orphanin FQ (N/OFQ) analogues modified in the Phe(1)-Gly(2) peptide bond are reported. The aim of the present work was to elucidate the importance of this peptide bond for the N/OFQ receptor (NOP) interaction. Our study indicates that the first peptide bond in N/OFQ is important but not crucial for interaction with the N/OFQ receptor; for instance, substitution with a methyleneoxy bond generates an agonist derivative just 3-fold less potent than the reference compound.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
10
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
365-8
|
|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:12565930-Animals,
pubmed-meshheading:12565930-Electric Stimulation,
pubmed-meshheading:12565930-Glycine,
pubmed-meshheading:12565930-Ligands,
pubmed-meshheading:12565930-Male,
pubmed-meshheading:12565930-Mice,
pubmed-meshheading:12565930-Muscle, Smooth,
pubmed-meshheading:12565930-Muscle Relaxation,
pubmed-meshheading:12565930-Opioid Peptides,
pubmed-meshheading:12565930-Peptides,
pubmed-meshheading:12565930-Phenylalanine,
pubmed-meshheading:12565930-Structure-Activity Relationship
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|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Nociceptin/Orphanin FQ(1-13)NH2 analogues modified in the Phe1-Gly2 peptide bond.
|
|
pubmed:affiliation |
Department of Pharmaceutical Sciences and Biotechnology Center, University of Ferrara, via Fossato di Mortara, 17/19, 44100 Ferrara, Italy. r.guerrini@unife.it
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|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
