Source:http://linkedlifedata.com/resource/pubmed/id/12419949
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2002-11-6
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pubmed:abstractText |
The inducer of differentiation of human promyelocytic leukemia HL-60 cells is commonly accepted to have potential therapeutic importance. Verticinone, one of the major isosteroidal alkaloids from the bulbus of Fritillaria ussuriensis, was found to inhibit the growth of HL-60 cells by inducing these cells to differentiate toward granulocytes. Importantly, the combination of verticinone with all-trans retinoic acid (ATRA), a well-known inducer of HL-60 cells into granulocytic lineages, was more effective than either alone, suggesting its therapeutic use in minimizing the effective dose of ATRA.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Cevanes,
http://linkedlifedata.com/resource/pubmed/chemical/Phytosterols,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/verticine
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0918-6158
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1409-11
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12419949-Alkaloids,
pubmed-meshheading:12419949-Cell Differentiation,
pubmed-meshheading:12419949-Cevanes,
pubmed-meshheading:12419949-Fritillaria,
pubmed-meshheading:12419949-HL-60 Cells,
pubmed-meshheading:12419949-Humans,
pubmed-meshheading:12419949-Leukemia, Promyelocytic, Acute,
pubmed-meshheading:12419949-Phytosterols,
pubmed-meshheading:12419949-Plant Extracts,
pubmed-meshheading:12419949-Plant Structures
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pubmed:year |
2002
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pubmed:articleTitle |
Differentiation-inducing effects of verticinone, an isosteroidal alkaloid isolated from the bulbus of Fritillaria ussuriensis, on human promyelocytic leukemia HL-60 cells.
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pubmed:affiliation |
Medicinal Resources Research Center of Wonkwang University, Iksan, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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