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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5594
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pubmed:dateCreated |
2002-10-25
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pubmed:abstractText |
N-methyl-D-aspartate receptors (NMDARs) mediate ischemic brain damage but also mediate essential neuronal excitation. To treat stroke without blocking NMDARs, we transduced neurons with peptides that disrupted the interaction of NMDARs with the postsynaptic density protein PSD-95. This procedure dissociated NMDARs from downstream neurotoxic signaling without blocking synaptic activity or calcium influx. The peptides, when applied either before or 1 hour after an insult, protected cultured neurons from excitotoxicity, reduced focal ischemic brain damage in rats, and improved their neurological function. This approach circumvents the negative consequences associated with blocking NMDARs and may constitute a practical stroke therapy.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Dlgh4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Dlgh4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/NR2B NMDA receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/postsynaptic density proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
298
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
846-50
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12399596-Amino Acid Sequence,
pubmed-meshheading:12399596-Animals,
pubmed-meshheading:12399596-Brain,
pubmed-meshheading:12399596-Brain Ischemia,
pubmed-meshheading:12399596-Calcium,
pubmed-meshheading:12399596-Cells, Cultured,
pubmed-meshheading:12399596-Cerebral Infarction,
pubmed-meshheading:12399596-Cyclic GMP,
pubmed-meshheading:12399596-Guanylate Kinase,
pubmed-meshheading:12399596-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12399596-Male,
pubmed-meshheading:12399596-Membrane Proteins,
pubmed-meshheading:12399596-Mice,
pubmed-meshheading:12399596-Mice, Inbred C57BL,
pubmed-meshheading:12399596-N-Methylaspartate,
pubmed-meshheading:12399596-Nerve Tissue Proteins,
pubmed-meshheading:12399596-Neurons,
pubmed-meshheading:12399596-Patch-Clamp Techniques,
pubmed-meshheading:12399596-Peptides,
pubmed-meshheading:12399596-Protein Binding,
pubmed-meshheading:12399596-Rats,
pubmed-meshheading:12399596-Rats, Sprague-Dawley,
pubmed-meshheading:12399596-Rats, Wistar,
pubmed-meshheading:12399596-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:12399596-Recombinant Fusion Proteins,
pubmed-meshheading:12399596-Signal Transduction,
pubmed-meshheading:12399596-Synaptic Transmission
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pubmed:year |
2002
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pubmed:articleTitle |
Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions.
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pubmed:affiliation |
Toronto Western Hospital Research Institute, 11-416 MC-PAV, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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