Linked Life Data

12393677

Source:http://linkedlifedata.com/resource/pubmed/id/12393677

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-12-17
pubmed:abstractText
Macrophages (MPhi) play a crucial role in the development of cutaneous granulomas (CGs) initiated by foreign bodies or invasive microorganisms. However, little is known about how MPhi are recruited to sites of CG formation. To test whether mast cells (MCs) contribute to early MPhi recruitment to developing granulomas, CGs were induced in MC-deficient Kit(W)/Kit(W-v) mice by injection of polyacrylamide gel (PAG). Kit(W)/Kit(W-v) mice as well as mice deficient in the MC product TNFalpha exhibited markedly reduced MPhi numbers in CGs. MPhi recruitment was restored in Kit(W)/Kit(W-v) mice reconstituted with MCs from Kit(+/+) or TNFalpha(+/+), but not from TNFalpha(-/-) mice. MC-TNFalpha-dependent MPhi influx required prior recruitment of MIP-1alpha/beta-producing neutrophils (PMNs), as PMN depletion before induction of CGs completely inhibited MPhi influx, which was restored after reconstitution with PMN supernatants. These findings indicate that MPhi recruitment to cutaneous PAG- induced granulomas is the result of a sequence of inflammatory processes initiated by MC-derived TNFalpha followed by PMN influx and MIP-1a/beta release.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
210-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Early macrophage influx to sites of cutaneous granuloma formation is dependent on MIP-1alpha /beta released from neutrophils recruited by mast cell-derived TNFalpha.
pubmed:affiliation
Department of Dermatology, University-Hospital Mainz, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't