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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0078063,
umls-concept:C0079281,
umls-concept:C0079282,
umls-concept:C0162801,
umls-concept:C0185117,
umls-concept:C1333329,
umls-concept:C1414260,
umls-concept:C1707455,
umls-concept:C2911684
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pubmed:dateCreated |
2002-8-23
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pubmed:databankReference |
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pubmed:abstractText |
Vasoactive intestinal contractor (VIC)/endothelin-2 (ET2) is a vasoactive peptide hormone comprising 21 amino acids. The complete nucleotide sequence of the full-length gene encoding preproVIC (PPVIC) was determined. The PPVIC gene contains five exons that span 6 kb and shows a duplication on exons 2 and 3, coding for the VIC and VIC-like peptides respectively. Similarities between the genomic organization of the PPVIC/preproET2 and preproendothelin-1 genes suggest that the two are distantly related. PPVIC gene expression was observed in foetal and adult mouse intestine. The expression level in adults was approx. 10-fold higher than in the foetus, suggesting an involvement of VIC in intestinal development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0143-5221
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
103 Suppl 48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
84S-89S
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12193061-Amino Acid Sequence,
pubmed-meshheading:12193061-Animals,
pubmed-meshheading:12193061-Base Sequence,
pubmed-meshheading:12193061-Cloning, Molecular,
pubmed-meshheading:12193061-Endothelin-1,
pubmed-meshheading:12193061-Endothelins,
pubmed-meshheading:12193061-Epithelial Cells,
pubmed-meshheading:12193061-Exons,
pubmed-meshheading:12193061-Gene Expression,
pubmed-meshheading:12193061-Humans,
pubmed-meshheading:12193061-Intestines,
pubmed-meshheading:12193061-Mesoderm,
pubmed-meshheading:12193061-Mice,
pubmed-meshheading:12193061-Molecular Sequence Data,
pubmed-meshheading:12193061-Muscle, Smooth,
pubmed-meshheading:12193061-Peptides,
pubmed-meshheading:12193061-Protein Precursors,
pubmed-meshheading:12193061-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12193061-Sequence Alignment,
pubmed-meshheading:12193061-Sequence Analysis, DNA
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pubmed:year |
2002
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pubmed:articleTitle |
Sequence analysis and expression of the mouse full-length vasoactive intestinal contractor/endothelin-2 gene (EDN2): comparison with the endothelin-1 gene (EDN1).
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pubmed:affiliation |
National Institute of Advanced Industrial Science and Technology, Ministry of Economy, Trade and Industry, Tsukuba, Ibaraki 305-8566, Japan. k.saida@aist.go.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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