Source:http://linkedlifedata.com/resource/umls/id/C0079282
MSH: A 21-amino acid peptide produced predominantly within the kidney and intestine, with smaller amounts produced in the myocardium, placenta, and uterus, but the cells of origin are not clear. Endothelin-2 has no unique physiologic functions, as compared with endothelin-1. (N Eng J Med 1995;333(6):356-63),NCI: Endothelin-2, encoded by the human EDN2 gene, is a macrophage chemoattractant. Endothelins are endothelium-derived vasoconstrictor peptides. The expression of this secreted protein by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia. (From LocusLink, Swiss-Prot and NCI)