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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-8-21
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pubmed:abstractText |
Mononuclear cells (MNC) from patients with aplastic anemia (AA) can inhibit hematopoietic colony formation from normal bone marrow (BM) cells. Interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) are considered as soluble mediators of BM suppression in AA. Because of its cytokine synthesis inhibiting action, interleukin-10 (IL-10) could be a potentially useful molecule to modulate the hematopoietic effects of MNC from patients with AA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1466-4860
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
206-13
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12189567-Adult,
pubmed-meshheading:12189567-Anemia, Aplastic,
pubmed-meshheading:12189567-Antibodies, Monoclonal,
pubmed-meshheading:12189567-Colony-Forming Units Assay,
pubmed-meshheading:12189567-Female,
pubmed-meshheading:12189567-Growth Inhibitors,
pubmed-meshheading:12189567-Humans,
pubmed-meshheading:12189567-Interferon-gamma,
pubmed-meshheading:12189567-Interleukin-10,
pubmed-meshheading:12189567-Leukocytes, Mononuclear,
pubmed-meshheading:12189567-Male,
pubmed-meshheading:12189567-Middle Aged,
pubmed-meshheading:12189567-Recombinant Proteins,
pubmed-meshheading:12189567-Tumor Necrosis Factor-alpha
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pubmed:year |
2002
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pubmed:articleTitle |
Interleukin-10 inhibits in vitro hematopoietic suppression and production of interferon-gamma and tumor necrosis factor-alpha by peripheral blood mononuclear cells from patients with aplastic anemia.
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pubmed:affiliation |
Division of Hematology, University of Vienna, Vienna, Austria. klaus.geissler@akh-wien.ac.at
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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