|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2002-9-2
|
|
pubmed:abstractText |
Angiogenesis is a highly regulated process that results from the sequential actions of naturally occurring stimulators and inhibitors. Here, we show that parathyroid hormone-related peptide, a peptide hormone derived from normal and tumor cells that regulates bone metabolism and vascular tone, is a naturally occurring angiogenesis inhibitor. Parathyroid hormone-related peptide or a ten-amino-acid peptide from its N terminus inhibits endothelial cell migration in vitro and angiogenesis in vivo by activating endothelial cell protein kinase A. Activation of protein kinase A inhibits cell migration and angiogenesis by inhibiting the small GTPase Rac. In contrast, inhibition of protein kinase A reverses the anti-migratory and anti-angiogenic properties of parathyroid hormone-related peptide. These studies show that parathyroid hormone-related peptide is a naturally occurring angiogenesis inhibitor that functions by activation of protein kinase A.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1078-8956
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
995-1003
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:12185361-Angiogenesis Inhibitors,
pubmed-meshheading:12185361-Animals,
pubmed-meshheading:12185361-Carcinogenicity Tests,
pubmed-meshheading:12185361-Cell Movement,
pubmed-meshheading:12185361-Chick Embryo,
pubmed-meshheading:12185361-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:12185361-Endothelium, Vascular,
pubmed-meshheading:12185361-Enzyme Inhibitors,
pubmed-meshheading:12185361-Fibroblast Growth Factor 2,
pubmed-meshheading:12185361-Gene Transfer Techniques,
pubmed-meshheading:12185361-Isoquinolines,
pubmed-meshheading:12185361-Mice,
pubmed-meshheading:12185361-Neovascularization, Pathologic,
pubmed-meshheading:12185361-Neovascularization, Physiologic,
pubmed-meshheading:12185361-Parathyroid Hormone-Related Protein,
pubmed-meshheading:12185361-Peptide Mapping,
pubmed-meshheading:12185361-Proteins,
pubmed-meshheading:12185361-Sulfonamides,
pubmed-meshheading:12185361-rac GTP-Binding Proteins
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor.
|
|
pubmed:affiliation |
University of California, San Diego Comprehensive Cancer Center, La Jolla, California, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|
