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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2002-8-16
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pubmed:abstractText |
A new strain of Babesia microti (KR-1) was isolated from a Connecticut resident with babesiosis by hamster inoculation and adapted to C3H/HeJ and BALB/c mice. To examine the relative importance of humoral and cellular immunity for the control of B. microti infection, we compared the course of disease in wild-type BALB/c mice with that in BALB/c SCID mice, JHD-null (B-cell-deficient) mice, and T-cell receptor alphabeta (TCRbeta(-/-)) or gamma interferon (IFN-gamma) (IFN-gamma(-/-)) knockout mice following inoculation with the KR-1-strain. SCID mice and TCRalphabeta knockouts sustained a severe but nonlethal parasitemia averaging 35 to 45% infected erythrocytes. IFN-gamma-deficient mice developed a less severe parasitemia but were able to clear the infection. In contrast, in six of eight JHD-null mice, the levels of parasitemia were indistinguishable from those in the wild-type animals. These data indicate that cellular immunity is critical for the clearance of B. microti in BALB/c mice but that disease resolution can occur even in the absence of IFN-gamma.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-10078490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-10417185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-10490951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-10618117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-10652120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-10768973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-10885987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-10958449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-11078770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-11227762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-11526189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-11687460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-11705985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-11724838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-11982307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-1500517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-2387628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-4610411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-480073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-6967703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-7365625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12183588-8410556
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5304-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12183588-Adult,
pubmed-meshheading:12183588-Animals,
pubmed-meshheading:12183588-Babesia,
pubmed-meshheading:12183588-Babesiosis,
pubmed-meshheading:12183588-Humans,
pubmed-meshheading:12183588-Immunity, Cellular,
pubmed-meshheading:12183588-Interferon-gamma,
pubmed-meshheading:12183588-Male,
pubmed-meshheading:12183588-Mice,
pubmed-meshheading:12183588-Mice, Inbred BALB C,
pubmed-meshheading:12183588-Mice, Knockout,
pubmed-meshheading:12183588-Mice, SCID,
pubmed-meshheading:12183588-Parasitemia,
pubmed-meshheading:12183588-Receptors, Antigen, T-Cell, alpha-beta
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pubmed:year |
2002
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pubmed:articleTitle |
Cellular immunity, but not gamma interferon, is essential for resolution of Babesia microti infection in BALB/c mice.
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pubmed:affiliation |
Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, Connecticut 06030-3710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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