Linked Life Data

12100017

Source:http://linkedlifedata.com/resource/pubmed/id/12100017

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-7-8
pubmed:abstractText
The beta-chemokines, RANTES, MIP-1alpha and MIP-1beta, have been implicated as being some of the protective factors in the immune response against human immunodeficiency virus (HIV) infection. We have presented data previously indicating that these chemokines also play a role in protective immunity against HIV/SIV infection in macaques. The aim of this study was to investigate the production of beta-chemokines in eight cynomolgus macaques vaccinated with non-pathogenic SHIV-4 in relation to protection against pathogenic SIVsm challenge. Four control animals were also included in the study. Two of the vaccinated monkeys were completely protected and one was partially protected against the challenge virus. The monkeys that resisted infectious SIVsm virus challenge showed higher spontaneous beta-chemokine production by peripheral blood mononuclear cells and had higher numbers of antigen-induced IFN-gamma secreting cells compared to the non-protected animals. Our observations support our previous findings that the genetic background of the host and/or environmental factors are involved in the chemokine production and that beta-chemokines contribute to protection against HIV/SIV infection.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-10075982, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-10217580, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-10357375, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-10417256, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-10423123, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-10518563, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-10545993, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-10570193, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-10669379, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-10671216, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-10885771, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-10979927, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-11014174, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-11034425, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-11095721, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-11251881, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-1613662, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-1706769, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-3134913, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-7682629, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-8597950, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-8658171, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-8673922, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-8751444, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-8752281, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-8756719, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-8827215, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-8871660, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-8898752, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-8918556, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-8989428, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9034141, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9060675, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9120386, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9188561, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9242519, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9259592, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9390747, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9400598, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9466518, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9516110, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9520457, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9560257, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9581779, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9675802, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9724785, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9739045, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9811776, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9863867, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9933172, http://linkedlifedata.com/resource/pubmed/commentcorrection/12100017-9987599
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...