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rdf:type |
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lifeskim:mentions |
umls-concept:C0015127,
umls-concept:C0215737,
umls-concept:C0332291,
umls-concept:C0332453,
umls-concept:C0458003,
umls-concept:C0678723,
umls-concept:C1257954,
umls-concept:C1314792,
umls-concept:C1524081,
umls-concept:C1565860,
umls-concept:C1705323
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pubmed:issue |
2
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pubmed:dateCreated |
2002-6-28
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pubmed:abstractText |
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the function of cyclooxygenases, COX-1 and COX-2, which catalyze the first step in the synthesis of inflammatory mediators (PGE2). We sought to understand the roles of cyclooxygenases and NSAIDs in T-cell development. Our data show no significant defects in T-cell development in fetal thymic organ cultures of mice disrupted in both or either COX genes or in mice disrupted in either EP-1 or EP-2 receptor genes. On the other hand, NSAIDs reproducibly caused thymocyte developmental defects. However, the specific effects of the COX-2 inhibitors were not correlated with their potency for inhibition of COX-2 activity. We focused on the NS-398 COX-2 inhibitor and showed that its effects could not be reversed by exogenous PGE2. Furthermore, NS-398 was inhibitory even when its target, COX-2, was absent. These data show that the T-cell developmental effects of NS-398 are COX-2 and PGE2 independent.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/DuP 697,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/N-(2-cyclohexyloxy-4-nitrophenyl)met...,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Ptger1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ptger2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ptgs1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E, EP1...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin E, EP2...,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Thiophenes
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0008-8749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
214
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
184-93
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12088417-Animals,
pubmed-meshheading:12088417-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:12088417-Cyclooxygenase 1,
pubmed-meshheading:12088417-Cyclooxygenase 2,
pubmed-meshheading:12088417-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:12088417-Cyclooxygenase Inhibitors,
pubmed-meshheading:12088417-Dinoprostone,
pubmed-meshheading:12088417-Immunologic Deficiency Syndromes,
pubmed-meshheading:12088417-Indomethacin,
pubmed-meshheading:12088417-Isoenzymes,
pubmed-meshheading:12088417-Membrane Proteins,
pubmed-meshheading:12088417-Mice,
pubmed-meshheading:12088417-Mice, Inbred C57BL,
pubmed-meshheading:12088417-Mice, Inbred DBA,
pubmed-meshheading:12088417-Mice, Knockout,
pubmed-meshheading:12088417-Nitrobenzenes,
pubmed-meshheading:12088417-Organ Culture Techniques,
pubmed-meshheading:12088417-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12088417-Receptors, Prostaglandin E,
pubmed-meshheading:12088417-Receptors, Prostaglandin E, EP1 Subtype,
pubmed-meshheading:12088417-Receptors, Prostaglandin E, EP2 Subtype,
pubmed-meshheading:12088417-Sulfonamides,
pubmed-meshheading:12088417-T-Lymphocytes,
pubmed-meshheading:12088417-Thiophenes,
pubmed-meshheading:12088417-Thymus Gland
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pubmed:year |
2001
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pubmed:articleTitle |
The COX-2 inhibitor NS-398 causes T-cell developmental disruptions independent of COX-2 enzyme inhibition.
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pubmed:affiliation |
Jerome H. Holland Laboratory for Biomedical Research, American Red Cross, Rockville, MD 20855, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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