Source:http://linkedlifedata.com/resource/pubmed/id/11859391
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2002-2-22
|
| pubmed:abstractText |
We performed stem cell rescue and allogeneic skin transplantation on a lethally neutron-irradiated nuclear accident victim. HLA-DRB1 mismatched unrelated umbilical cord blood cells (2.08 x 10(7)/kg recipient body weight) were transplanted to an 8-10 Gy equivalent neutron-irradiated patient because of a lack of a suitable bone marrow or peripheral blood donor. Pre-transplant conditioning consisted of anti-thymocyte gamma-globulin alone, and GVHD prophylaxis was a combination of cyclosporine (CYA) and methylprednisolone (mPSL). Granulocyte colony-stimulating factor (G-CSF), erythropoietin (EPO), and thrombopoietin (TPO) were concurrently administered after transplantation. The absolute neutrophil count reached 0.5 x 10(9)/l on day 15, the reticulocyte count rose above 1% on day 23, and the platelet count was over 50 x 10(9)/l on day 27, respectively. Cytogenetic studies of blood and marrow showed donor/recipient mixed chimerism. Rapid autologous hematopoietic recovery was recognized after withdrawal of CYA and mPSL. Repeated pathological examinations of the skin revealed no evidence of acute GVHD. Eighty-two days after the irradiation, skin transplantation was performed to treat radiation burns. Almost 90% of the transplanted skin engrafted. Immunological examination after autologous hematopoietic recovery revealed an almost normal T cell count. However, immune functions were severely impaired. The patient died from infectious complication 210 days after the accident.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0268-3369
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| pubmed:author |
pubmed-author:BRUCKM AMA,
pubmed-author:IsekiTT,
pubmed-author:JiT HTH,
pubmed-author:KodoHH,
pubmed-author:MisawaKK,
pubmed-author:NagayamaHH,
pubmed-author:RottN NNN,
pubmed-author:ShimazakiSS,
pubmed-author:TakahashiT ATA,
pubmed-author:TanakaHH,
pubmed-author:TaneGG,
pubmed-author:YamadaYY,
pubmed-author:YamashitaNN
|
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
197-204
|
| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:11859391-Adult,
pubmed-meshheading:11859391-Fatal Outcome,
pubmed-meshheading:11859391-Fetal Blood,
pubmed-meshheading:11859391-Graft Survival,
pubmed-meshheading:11859391-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:11859391-Histocompatibility Testing,
pubmed-meshheading:11859391-Humans,
pubmed-meshheading:11859391-Immune System,
pubmed-meshheading:11859391-Male,
pubmed-meshheading:11859391-Neutrons,
pubmed-meshheading:11859391-Radiation Dosage,
pubmed-meshheading:11859391-Radiation Injuries,
pubmed-meshheading:11859391-Radioactive Hazard Release,
pubmed-meshheading:11859391-Respiratory Distress Syndrome, Adult,
pubmed-meshheading:11859391-Skin Transplantation,
pubmed-meshheading:11859391-Transplantation, Homologous,
pubmed-meshheading:11859391-Transplantation Chimera
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Transient hematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victim.
|
| pubmed:affiliation |
Institute of Medical Science, University of Tokyo, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|