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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-2-13
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pubmed:abstractText |
To investigate the efficacy and safety of granulocyte colony-stimulating factor (G-CSF) in patients with acute myelogenous leukaemia, a multicentre randomized study was performed. From October 1993 to September 1996, 270 patients with newly diagnosed acute myelogenous leukaemia were randomized to G-CSF or control groups after remission induction therapy. The G-CSF group received G-CSF (Filgrastim) from 48 h after the completing chemotherapy until the absolute neutrophil count exceeded 1.5 x 10(9)/l. The control group did not receive G-CSF unless severe infection occurred. There were 245 evaluable patients (120 and 125 in the G-CSF and control groups respectively). The complete remission rate was similar in the G-CSF and control groups (80.8% versus 76.8%), as was the 5-year probability of disease-free survival (34.5% versus 33.6%) and overall survival (42.7% versus 35.6%). Neutrophil recovery was significantly faster in the G-CSF group than in the control group (12 d versus 18 d, P = 0.0001). The median duration of febrile neutropenia was significantly shorter in the G-CSF group than in the control group (3 d versus 4 d, P = 0.0001). In conclusion, prophylactic administration of G-CSF after remission induction therapy for acute myelogenous leukaemia is safe and useful even in patients without infection on completing chemotherapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0007-1048
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pubmed:author |
pubmed-author:AbeTsukasaT,
pubmed-author:DilsaverS CSC,
pubmed-author:Gran AML Study Group,
pubmed-author:HamajimaNobuyukiN,
pubmed-author:HoriuchiAtsushiA,
pubmed-author:IkedaYasuoY,
pubmed-author:IrinoSyozoS,
pubmed-author:KimuraIkurouI,
pubmed-author:KuramotoAtsushiA,
pubmed-author:MasaokaToruT,
pubmed-author:MatsudaTamotsuT,
pubmed-author:MiuraAkiraA,
pubmed-author:MiuraYasusadaY,
pubmed-author:MiyazakiTamotsuT,
pubmed-author:MizoguchiHideakiH,
pubmed-author:NagaoTadamiT,
pubmed-author:NakamuraToruT,
pubmed-author:NihoYoshiyukiY,
pubmed-author:NiitsuYousirouY,
pubmed-author:NomuraTakeoT,
pubmed-author:OhkumaMinoruM,
pubmed-author:OhnoRyuzoR,
pubmed-author:ShibataAkiraA,
pubmed-author:ShirakawaShigeruS,
pubmed-author:TakakuFumimaroF,
pubmed-author:TakatsukiKiyoshiK,
pubmed-author:TomonagaMasaoM,
pubmed-author:UchinoHarutoH,
pubmed-author:UrabeAkioA,
pubmed-author:UsukiKensukeK,
pubmed-author:YoshidaYutakaY
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pubmed:issnType |
Print
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
103-12
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11841402-Adolescent,
pubmed-meshheading:11841402-Adult,
pubmed-meshheading:11841402-Aged,
pubmed-meshheading:11841402-Anti-Bacterial Agents,
pubmed-meshheading:11841402-Bacterial Infections,
pubmed-meshheading:11841402-Chi-Square Distribution,
pubmed-meshheading:11841402-Disease-Free Survival,
pubmed-meshheading:11841402-Female,
pubmed-meshheading:11841402-Fever,
pubmed-meshheading:11841402-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:11841402-Humans,
pubmed-meshheading:11841402-Leukemia, Myeloid, Acute,
pubmed-meshheading:11841402-Leukocyte Count,
pubmed-meshheading:11841402-Male,
pubmed-meshheading:11841402-Middle Aged,
pubmed-meshheading:11841402-Neutropenia,
pubmed-meshheading:11841402-Recombinant Proteins,
pubmed-meshheading:11841402-Remission Induction
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pubmed:year |
2002
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pubmed:articleTitle |
Efficacy of granulocyte colony-stimulating factor in the treatment of acute myelogenous leukaemia: a multicentre randomized study.
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pubmed:affiliation |
Division of Hematology, NTT Kanto Medical Center, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Multicenter Study
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