Source:http://linkedlifedata.com/resource/pubmed/id/11806031
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
2002-1-24
|
pubmed:abstractText |
Covering a stent with a membrane (stent graft) allows treatment of diverse coronary abnormalities such as aneurysms, rupture and fistulas (which, until recently, required surgical therapy). A stent graft could also reduce embolic complications associated with angioplasty of saphenous vein grafts. The objective of this study is to evaluate bovine pericardium as a graft for conventional stents. In vitro testing of the bovine pericardium disclosed an elasticity of 15% and a resistance to rupture of 0.22 kg/mm2, well above the pressure commonly used during stent deployment. In 18 pigs, 29 of 32 (90.63%) attempts to implant stent grafts were successful. Histology of acute porcine studies revealed correct apposition of the stent graft to the vessel wall, subacute and chronic (10 days and 1 month) samples showed adequate endothelization and exclusion of proliferative media. Twenty stents were placed in 15 patients with a 100% success rate. Seven patients had coronary aneurysms and in all a complete exclusion of the aneurysm was obtained without complications. Fourteen patients have a follow-up of 6 or more months with evidence of clinical restenosis in 2 (14.28%), whereas angiographic follow-up in 9 patients, which included the 2 cases with recurrent angina, evidenced restenosis in 3 of 14 stents (21.4%), two of which were overlapped in the LAD of one patient and one corresponded to a series of 9 stents (in 5 patients) placed in saphenous vein grafts. It is concluded that bovine pericardium is a suitable material for stent-grafts and its efficacy to seal coronary aneurysms was demonstrated. These results warrant a larger comparative study to better define its restenosis rate and further delineate its usefulness in the treatment of diseased saphenous vein grafts.
|
pubmed:language |
spa
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
1405-9940
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
71
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
286-94
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:11806031-Animals,
pubmed-meshheading:11806031-Cattle,
pubmed-meshheading:11806031-Coated Materials, Biocompatible,
pubmed-meshheading:11806031-Female,
pubmed-meshheading:11806031-Humans,
pubmed-meshheading:11806031-Male,
pubmed-meshheading:11806031-Middle Aged,
pubmed-meshheading:11806031-Pericardium,
pubmed-meshheading:11806031-Stents,
pubmed-meshheading:11806031-Swine,
pubmed-meshheading:11806031-Vascular Diseases
|
pubmed:articleTitle |
[Stent coated with bovine pericardium: in vitro evaluation, in animals, and initial results in humans].
|
pubmed:affiliation |
Departamento de Hemodinámica, Instituto Nacional de Cardiología Ignacio Chávez, INCICH, Juan Badiano No. 1, México D.F.
|
pubmed:publicationType |
Journal Article,
In Vitro,
English Abstract
|