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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-1-11
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pubmed:abstractText |
Proximal tubule epithelial cells (PTEC) play a central role in the response of the kidney to insult by virtue of their production of chemokines and cytokines that signal an inflammatory response. Bone morphogenic protein-7 (BMP-7/OP-1), a member of the transforming growth factor-beta (TGF-beta) superfamily, has previously been demonstrated to reduce macrophage infiltration and tissue damage in animal models of acute and chronic renal failure. The present study was designed to define the molecular mechanism of BMP-7 action in human PTEC.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BMP7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 7,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Differentiation Factor 5,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/ID3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TGFB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
51-60
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11786084-Animals,
pubmed-meshheading:11786084-Bone Morphogenetic Protein 7,
pubmed-meshheading:11786084-Bone Morphogenetic Protein Receptors,
pubmed-meshheading:11786084-Bone Morphogenetic Proteins,
pubmed-meshheading:11786084-Cells, Cultured,
pubmed-meshheading:11786084-Chemokine CCL2,
pubmed-meshheading:11786084-Chemokines,
pubmed-meshheading:11786084-DNA Primers,
pubmed-meshheading:11786084-DNA-Binding Proteins,
pubmed-meshheading:11786084-Endothelin-2,
pubmed-meshheading:11786084-Gene Expression,
pubmed-meshheading:11786084-Growth Differentiation Factor 5,
pubmed-meshheading:11786084-Growth Substances,
pubmed-meshheading:11786084-Humans,
pubmed-meshheading:11786084-Inhibitor of Differentiation Proteins,
pubmed-meshheading:11786084-Interleukin-1,
pubmed-meshheading:11786084-Interleukin-6,
pubmed-meshheading:11786084-Interleukin-8,
pubmed-meshheading:11786084-Kidney Tubules, Proximal,
pubmed-meshheading:11786084-Lac Operon,
pubmed-meshheading:11786084-Mice,
pubmed-meshheading:11786084-Mice, Transgenic,
pubmed-meshheading:11786084-Neoplasm Proteins,
pubmed-meshheading:11786084-Neutrophils,
pubmed-meshheading:11786084-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:11786084-RNA, Messenger,
pubmed-meshheading:11786084-Receptors, Cell Surface,
pubmed-meshheading:11786084-Receptors, Growth Factor,
pubmed-meshheading:11786084-Renal Circulation,
pubmed-meshheading:11786084-Transcription Factors,
pubmed-meshheading:11786084-Transforming Growth Factor beta,
pubmed-meshheading:11786084-Transforming Growth Factor beta1,
pubmed-meshheading:11786084-Vasoconstriction
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pubmed:year |
2002
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pubmed:articleTitle |
BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells.
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pubmed:affiliation |
Curis, Inc., Cambridge, Massachusetts 02138, USA. sgould@curis.com
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pubmed:publicationType |
Journal Article
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