Linked Life Data

11522378

Source:http://linkedlifedata.com/resource/pubmed/id/11522378

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2001-8-27
pubmed:abstractText
Fumonisin B1 (FB1), a potent mycotoxin prevalent in corn, is a carcinogen and causative agent of various animal diseases. Species and sex variations to chronic FB1 toxicity have been reported. Free sphingoid bases and cytokine levels are the two major biochemical alterations of FB1 in vivo and may explain any sex differences in FB1 toxicity. Male and female BALB/c mice (5/group) were injected subcutaneously with either saline vehicle or 2.25 mg/kg/day of FB1 for 5 days. One day after the last injection females showed a greater increase in circulating alanine aminotransferase and greater number of apoptotic cells in liver after FB1 treatment than males, indicating greater hepatotoxicity. Peripheral leukocytic counts, including neutrophils, were increased in females only after FB1 treatment. The increased toxicity in females correlated with a greater increase of sphinganine and sphingosine levels in liver after FB1 treatment compared to males. No sex differences in kidney sphinganine or sphingosine levels were observed after FB1 treatment. Previously we have shown the induction of tumor necrosis factor alpha (TNFalpha) in FB1-induced hepatotoxicity. While in males FB1 treatment caused increased expression of TNFalpha, interleukin (IL)-12 p40, interferon gamma (IFNgamma), IL-1beta, IL-6 and IL-10, females showed an increased expression of IL-6 only, and a downward modulation of IFNgamma, indicating gender differences in cytokine pathways in liver activated by FB1. The basal expression of TNFalpha, IL-12 p40, IL-1beta and IFNgamma in liver of females was higher compared to males. Gender differences in alterations of free sphingoid bases and cytokine modulation after FB1 treatment suggest their possible involvement in sex-dependent differential hepatotoxicity in mice.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
165
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-204
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11522378-Alanine Transaminase, pubmed-meshheading:11522378-Animals, pubmed-meshheading:11522378-Aspartate Aminotransferases, pubmed-meshheading:11522378-Carboxylic Acids, pubmed-meshheading:11522378-Carcinogens, Environmental, pubmed-meshheading:11522378-Cytokines, pubmed-meshheading:11522378-Drug-Induced Liver Injury, pubmed-meshheading:11522378-Erythrocyte Count, pubmed-meshheading:11522378-Female, pubmed-meshheading:11522378-Fumonisins, pubmed-meshheading:11522378-Kidney, pubmed-meshheading:11522378-Leukocyte Count, pubmed-meshheading:11522378-Liver, pubmed-meshheading:11522378-Male, pubmed-meshheading:11522378-Mice, pubmed-meshheading:11522378-Mice, Inbred BALB C, pubmed-meshheading:11522378-Mycotoxins, pubmed-meshheading:11522378-Sex Factors, pubmed-meshheading:11522378-Sphingosine
pubmed:year
2001
pubmed:articleTitle
Gender-related differences in subacute fumonisin B1 hepatotoxicity in BALB/c mice.
pubmed:affiliation
Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602-7389, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.