|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0021469,
umls-concept:C0026473,
umls-concept:C0043047,
umls-concept:C0079488,
umls-concept:C0086418,
umls-concept:C0142971,
umls-concept:C1280500,
umls-concept:C1456820,
umls-concept:C1555707,
umls-concept:C1705851,
umls-concept:C1819435,
umls-concept:C1948023,
umls-concept:C2752151,
umls-concept:C2828366
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2001-7-12
|
|
pubmed:abstractText |
We investigated the effect of sofalcone, a synthetic flavonoid derivative of sophoradin, on tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta production in human monocytes stimulated by Helicobacter pylori water extract. H. pylori water extract significantly stimulated TNF-alpha and IL-1 beta production by monocytes while incubation with sofalcone (10 micrograms/ml and 50 micrograms/ml) significantly inhibited this increase in TNF-alpha and IL-1 beta production. These results suggest that sofalcone could be used to improve H. pylori-associated gastric mucosal inflammation through inhibition of proinflammatory cytokine production.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0378-6501
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
103-6
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Inhibitory effect of sofalcone on tumor necrosis factor-alpha and interleukin-1 beta production in human monocytes stimulated by Helicobacter pylori water extract.
|
|
pubmed:affiliation |
Department of Gastroenterology, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku Osaka 545-8585, Japan. yasu@med.osaka-cu.acjp
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
