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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003591,
umls-concept:C0008377,
umls-concept:C0023779,
umls-concept:C0024432,
umls-concept:C0026809,
umls-concept:C0035647,
umls-concept:C0040300,
umls-concept:C0085201,
umls-concept:C0205178,
umls-concept:C0332461,
umls-concept:C0392756,
umls-concept:C0456205,
umls-concept:C1550605,
umls-concept:C1637379
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|
pubmed:issue |
25
|
|
pubmed:dateCreated |
2001-6-26
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|
pubmed:abstractText |
Repeated doses of recombinant apolipoprotein A-I(Milano) phospholipid complex (apoA-I(m)) reduce atherosclerosis and favorably change plaque composition in rabbits and mice. In this study, we tested whether a single high dose of recombinant apoA-I(m) could rapidly mobilize tissue cholesterol and reduce plaque lipid and macrophage content in apoE-deficient mice.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
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pubmed:issn |
1524-4539
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|
pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
26
|
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pubmed:volume |
103
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
3047-50
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11425766-1,2-Dipalmitoylphosphatidylcholine,
pubmed-meshheading:11425766-Animals,
pubmed-meshheading:11425766-Apolipoprotein A-I,
pubmed-meshheading:11425766-Apolipoproteins E,
pubmed-meshheading:11425766-Arteriosclerosis,
pubmed-meshheading:11425766-Cholesterol,
pubmed-meshheading:11425766-Dose-Response Relationship, Drug,
pubmed-meshheading:11425766-Lipid Metabolism,
pubmed-meshheading:11425766-Macrophages,
pubmed-meshheading:11425766-Mice,
pubmed-meshheading:11425766-Mice, Inbred C57BL,
pubmed-meshheading:11425766-Mice, Knockout,
pubmed-meshheading:11425766-Recombinant Proteins,
pubmed-meshheading:11425766-Sinus of Valsalva
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|
pubmed:year |
2001
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|
pubmed:articleTitle |
High-dose recombinant apolipoprotein A-I(milano) mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein e-deficient mice. Potential implications for acute plaque stabilization.
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pubmed:affiliation |
Atherosclerosis Research Center, the Division of Cardiology, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, Calif and Esperion Therapeutics Inc, Ann Arbor, Michigan, USA. shahp@cshs.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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