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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2001-6-20
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pubmed:abstractText |
The Caenorhabditis elegans excretory cell extends tubular processes, called canals, along the basolateral surface of the epidermis. Mutations in the exc-5 gene cause tubulocystic defects in this canal. Ultrastructural analysis suggests that exc-5 is required for the proper placement of cytoskeletal elements at the apical epithelial surface. exc-5 encodes a protein homologous to guanine nucleotide exchange factors and contains motif architecture similar to that of FGD1, which is responsible for faciogenital dysplasia. exc-5 interacts genetically with mig-2, which encodes Rho GTPase. These results suggest that EXC-5 controls the structural organization of the excretory canal by regulating Rho family GTPase activities.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-10393177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-10464238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-10491271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-10707082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-1321065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-1935914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-3308403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-6827646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-7743993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-7744961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-7954831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-8582641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-8791419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-8824291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-8973370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-8994827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-9298900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-9438836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-9624130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11415987-9668039
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1469-221X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
530-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11415987-Amino Acid Sequence,
pubmed-meshheading:11415987-Animals,
pubmed-meshheading:11415987-Animals, Genetically Modified,
pubmed-meshheading:11415987-Caenorhabditis elegans,
pubmed-meshheading:11415987-Caenorhabditis elegans Proteins,
pubmed-meshheading:11415987-Chromosome Mapping,
pubmed-meshheading:11415987-DNA, Complementary,
pubmed-meshheading:11415987-Exons,
pubmed-meshheading:11415987-Guanine Nucleotide Exchange Factors,
pubmed-meshheading:11415987-Helminth Proteins,
pubmed-meshheading:11415987-Introns,
pubmed-meshheading:11415987-Microscopy, Electron,
pubmed-meshheading:11415987-Models, Genetic,
pubmed-meshheading:11415987-Molecular Sequence Data,
pubmed-meshheading:11415987-Mutation,
pubmed-meshheading:11415987-Plasmids,
pubmed-meshheading:11415987-Protein Binding
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pubmed:year |
2001
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pubmed:articleTitle |
A putative GDP-GTP exchange factor is required for development of the excretory cell in Caenorhabditis elegans.
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pubmed:affiliation |
Department of Molecular Biology, Graduate school of Science, Nagoya University and CREST, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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