| pubmed-article:11343213 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11343213 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11343213 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:11343213 | lifeskim:mentions | umls-concept:C0225335 | lld:lifeskim |
| pubmed-article:11343213 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
| pubmed-article:11343213 | lifeskim:mentions | umls-concept:C0063695 | lld:lifeskim |
| pubmed-article:11343213 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:11343213 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:11343213 | lifeskim:mentions | umls-concept:C0600210 | lld:lifeskim |
| pubmed-article:11343213 | lifeskim:mentions | umls-concept:C0813983 | lld:lifeskim |
| pubmed-article:11343213 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:11343213 | pubmed:dateCreated | 2001-5-8 | lld:pubmed |
| pubmed-article:11343213 | pubmed:abstractText | Migration of polymorphonuclear neutrophils (PMNL) from the vascular compartment into the pleural space occurs rapidly during the development of parapneumonic effusions. This study investigated the polarized secretion of interleukin (IL)-8 in activated pleural mesothelial cells (PMC) and the migration of PMNL across resting, activated PMC monolayers. Results show that PMC produce IL-8 in a polar manner. When PMC were stimulated with Staphylococcus aureus or IL-1beta at the basal or at the apical surface, significantly (P< .05) more IL-8 was released toward the apical surface. This polarized production of IL-8 was confirmed by in situ hybridization. PMNL migration was higher from the basilar to apical than from the apical to basilar surface of PMC. Neutralizing antibodies against IL-8 and intercellular adhesion molecule (ICAM)-1 significantly (P< .001) blocked PMNL migration across activated monolayers. Thus, during pleural inflammation, PMC regulate the influx of PMNL into the pleural space by polar production of IL-8 and expression of ICAM-1. | lld:pubmed |
| pubmed-article:11343213 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11343213 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11343213 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11343213 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11343213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11343213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11343213 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11343213 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11343213 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:11343213 | pubmed:author | pubmed-author:MohammedK AKA | lld:pubmed |
| pubmed-article:11343213 | pubmed:author | pubmed-author:DoerschukC... | lld:pubmed |
| pubmed-article:11343213 | pubmed:author | pubmed-author:HouyJ CJC | lld:pubmed |
| pubmed-article:11343213 | pubmed:author | pubmed-author:AntonyV BVB | lld:pubmed |
| pubmed-article:11343213 | pubmed:author | pubmed-author:HardwickJJ | lld:pubmed |
| pubmed-article:11343213 | pubmed:author | pubmed-author:SandersK LKL | lld:pubmed |
| pubmed-article:11343213 | pubmed:author | pubmed-author:NasreenNN | lld:pubmed |
| pubmed-article:11343213 | pubmed:author | pubmed-author:Van HornR DRD | lld:pubmed |
| pubmed-article:11343213 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11343213 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11343213 | pubmed:volume | 183 | lld:pubmed |
| pubmed-article:11343213 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11343213 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11343213 | pubmed:pagination | 1638-45 | lld:pubmed |
| pubmed-article:11343213 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11343213 | pubmed:meshHeading | pubmed-meshheading:11343213... | lld:pubmed |
| pubmed-article:11343213 | pubmed:meshHeading | pubmed-meshheading:11343213... | lld:pubmed |
| pubmed-article:11343213 | pubmed:meshHeading | pubmed-meshheading:11343213... | lld:pubmed |
| pubmed-article:11343213 | pubmed:meshHeading | pubmed-meshheading:11343213... | lld:pubmed |
| pubmed-article:11343213 | pubmed:meshHeading | pubmed-meshheading:11343213... | lld:pubmed |
| pubmed-article:11343213 | pubmed:meshHeading | pubmed-meshheading:11343213... | lld:pubmed |
| pubmed-article:11343213 | pubmed:meshHeading | pubmed-meshheading:11343213... | lld:pubmed |
| pubmed-article:11343213 | pubmed:meshHeading | pubmed-meshheading:11343213... | lld:pubmed |
| pubmed-article:11343213 | pubmed:meshHeading | pubmed-meshheading:11343213... | lld:pubmed |
| pubmed-article:11343213 | pubmed:meshHeading | pubmed-meshheading:11343213... | lld:pubmed |
| pubmed-article:11343213 | pubmed:meshHeading | pubmed-meshheading:11343213... | lld:pubmed |
| pubmed-article:11343213 | pubmed:meshHeading | pubmed-meshheading:11343213... | lld:pubmed |
| pubmed-article:11343213 | pubmed:meshHeading | pubmed-meshheading:11343213... | lld:pubmed |
| pubmed-article:11343213 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11343213 | pubmed:articleTitle | Polar production of interleukin-8 by mesothelial cells promotes the transmesothelial migration of neutrophils: role of intercellular adhesion molecule-1. | lld:pubmed |
| pubmed-article:11343213 | pubmed:affiliation | Division of Pulmonary and Critical Care Medicine, Department of Veterans Affairs Medical Center, and Indiana University School of Medicine, Indianapolis, IN, USA. | lld:pubmed |
| pubmed-article:11343213 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11343213 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:11343213 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11343213 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11343213 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11343213 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11343213 | lld:pubmed |
